Cytokeratin 15 Inhibitors
Cytokeratin 15 inhibitors encompass a diverse array of compounds that either directly or indirectly modulate the expression and function of Cytokeratin 15. Cytokeratin 15, a member of the intermediate filament family, plays a crucial role in maintaining the structural integrity of cells and is implicated in various cellular processes, including cell proliferation, migration, and cytoskeletal organization. Several microtubule-targeting agents have been identified as direct inhibitors of Cytokeratin 15. Nocodazole, vinblastine, and colchicine disrupt microtubule dynamics by either depolymerizing or stabilizing microtubules, leading to alterations in Cytokeratin 15 structure and function. These agents highlight the intimate relationship between microtubules and intermediate filaments, emphasizing the impact of cytoskeletal cross-talk on Cytokeratin 15 regulation. Histone deacetylase 6 (HDAC6) inhibitors, such as tubastatin A, indirectly influence Cytokeratin 15 by modulating tubulin acetylation. Tubastatin A, by inhibiting HDAC6, increases tubulin acetylation, enhancing microtubule stability. This indirect modulation underscores the role of epigenetic regulation in coordinating cytoskeletal dynamics and provides insights into the avenues for controlling Cytokeratin 15 expression.
Agents targeting DNA processes also impact Cytokeratin 15. For instance, cisplatin, bleomycin, and etoposide induce DNA damage and trigger apoptotic pathways, indirectly influencing Cytokeratin 15 expression. These findings emphasize the complex interplay between DNA damage response pathways and the regulation of intermediate filament proteins like Cytokeratin 15. Additionally, myosin II inhibitors, such as blebbistatin, indirectly affect Cytokeratin 15 by disrupting actin cytoskeleton dynamics. Blebbistatin inhibits myosin II ATPase activity, impairing actin filament contraction and altering cellular morphology. This indirect modulation highlights the interconnected nature of the cytoskeleton and the coordinated control of actin and intermediate filaments. In conclusion, the chemical class of Cytokeratin 15 inhibitors provides a comprehensive understanding of the diverse mechanisms by which compounds modulate the expression and function of this intermediate filament protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol is a microtubule stabilizer that inhibits Cytokeratin 15 indirectly by disrupting microtubule dynamics. By binding to tubulin and promoting microtubule polymerization, Taxol interferes with the normal functions of the cytoskeleton, leading to mitotic arrest and ultimately inhibiting cell proliferation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a platinum-based chemotherapeutic agent, is an indirect inhibitor of Cytokeratin 15. It forms DNA crosslinks, inducing DNA damage and triggering apoptotic pathways. The downstream effects of cisplatin on cell survival and apoptosis modulation can indirectly impact Cytokeratin 15 expression and function. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is an indirect inhibitor of Cytokeratin 15, primarily affecting cell proliferation. As a thymidylate synthase inhibitor, 5-FU disrupts DNA synthesis and inhibits cell division. The downstream impact on cell cycle progression and proliferation indirectly influences the expression and function of Cytokeratin 15. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole, a microtubule-depolymerizing agent, is a direct inhibitor of Cytokeratin 15 by disrupting microtubule dynamics. By inhibiting tubulin polymerization and promoting microtubule depolymerization, nocodazole interferes with the normal organization of the cytoskeleton, leading to alterations in Cytokeratin 15 structure and function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a myosin II inhibitor that indirectly influences Cytokeratin 15 by disrupting actin cytoskeleton dynamics. By inhibiting myosin II ATPase activity, blebbistatin impairs actin filament contraction and alters cellular morphology. The downstream effects on actin dynamics indirectly impact Cytokeratin 15 organization and function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine, a microtubule-depolymerizing agent, is a direct inhibitor of Cytokeratin 15 by disrupting microtubule dynamics. By binding to tubulin and inhibiting microtubule polymerization, vinblastine interferes with the normal functions of the cytoskeleton, leading to alterations in Cytokeratin 15 structure and function. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $85.00 $325.00 $1072.00 | 16 | |
Docetaxel is a microtubule stabilizer that indirectly inhibits Cytokeratin 15 by promoting microtubule stability. By binding to tubulin and enhancing microtubule polymerization, docetaxel disrupts the dynamic equilibrium of microtubules, leading to mitotic arrest and inhibiting cell proliferation. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin, a DNA-damaging antibiotic, is an indirect inhibitor of Cytokeratin 15. By inducing DNA strand breaks and generating reactive oxygen species (ROS), bleomycin triggers apoptotic pathways. The downstream effects on cell survival and apoptosis modulation can indirectly impact Cytokeratin 15 expression and function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine, a microtubule-depolymerizing agent, is a direct inhibitor of Cytokeratin 15 by disrupting microtubule dynamics. By binding to tubulin and inhibiting microtubule polymerization, colchicine interferes with the normal organization of the cytoskeleton, leading to alterations in Cytokeratin 15 structure and function. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, is an indirect inhibitor of Cytokeratin 15. By inducing DNA double-strand breaks and interfering with DNA repair mechanisms, etoposide triggers apoptotic pathways. | ||||||