Cyp4f37 Activators
Cyp4f37, a member of the cytochrome P450 family, is an enzyme that plays a critical role in cellular lipid metabolism within the context of the broader family of P450 enzymes. Its primary function involves the oxidation of various fatty acids, contributing to the intricate network of biochemical pathways associated with lipid homeostasis. The enzyme is particularly involved in the biotransformation of fatty acids, serving as a key player in the regulation of lipid metabolism and the maintenance of cellular homeostasis. Its substrate specificity for fatty acids positions Cyp4f37 as a crucial component in the cellular response to changes in lipid levels, thereby influencing diverse physiological processes, including energy balance and cellular signaling cascades related to lipid-derived molecules.
The activation of Cyp4f37 is a complex and finely regulated process orchestrated by a myriad of endogenous and exogenous factors. These factors include specific classes of chemicals, such as thiazolidinediones, retinoic acid, polyunsaturated fatty acids, and others, which either directly engage with Cyp4f37 or modulate related signaling pathways. These interactions trigger distinct mechanisms of activation, encompassing direct substrate binding, conformational changes, and transcriptional regulation. For instance, ligands like retinoic acid bind directly to regulatory elements, inducing conformational changes in Cyp4f37 that enhance its enzymatic activity. On the other hand, polyunsaturated fatty acids serve as substrates for Cyp4f37 metabolism, leading to the generation of bioactive lipids that act as signaling molecules. Furthermore, indirect activators, including those that interact with nuclear receptors such as PPARs and Nrf2, influence cellular pathways that culminate in enhanced Cyp4f37 expression. This intricate regulatory network highlights the adaptability of Cyp4f37 in responding to various environmental cues, contributing to the dynamic control of lipid metabolism and cellular processes associated with fatty acids.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan activates Cyp4f17 by modulating the PPARγ pathway. It acts as a ligand for PPARγ, leading to increased Cyp4f17 transcription. PPARγ binding induces downstream effects on lipid metabolism, enhancing Cyp4f17 expression via a positive feedback loop. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol indirectly activates Cyp4f17 by inhibiting the SIRT1 pathway. Suppression of SIRT1 enhances PPARγ activity, resulting in upregulated Cyp4f17 expression. This modulation exploits the crosstalk between SIRT1 and PPARγ pathways to stimulate Cyp4f17. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic Acid directly upregulates Cyp4f17 by serving as a substrate for CYP enzymes. It undergoes metabolism by Cyp4f17, producing bioactive lipids that act as signaling molecules. This autoregulatory loop amplifies Cyp4f17 activity, contributing to its sustained activation. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate activates Cyp4f17 through PPARα stimulation. Acting as a PPARα agonist, fenofibrate enhances the transcriptional activity of PPARα, promoting the expression of Cyp4f17 and subsequent metabolic responses associated with lipid oxidation. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $83.00 $272.00 | 1 | |
Lithocholic Acid acts as a direct activator of Cyp4f17 by interacting with its catalytic site. This bile acid substrate facilitates the enzymatic activity of Cyp4f17, leading to increased metabolite production. The activation contributes to lipid homeostasis and cellular responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane indirectly stimulates Cyp4f17 through NRF2 pathway modulation. By activating NRF2, sulforaphane enhances the antioxidant response, indirectly promoting Cyp4f17 expression. This secondary activation highlights the interconnectedness of cellular stress responses. | ||||||
4-Hydroxynonenal | 75899-68-2 | sc-202019 sc-202019A sc-202019B | 1 mg 10 mg 50 mg | $116.00 $642.00 $2720.00 | 25 | |
4-Hydroxynonenal, a lipid peroxidation product, directly activates Cyp4f17 by forming adducts with the enzyme. This covalent modification induces conformational changes in Cyp4f17, leading to increased catalytic activity and enhanced metabolic functions related to lipid processing. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 stimulates Cyp4f17 by engaging with its regulatory elements. Acting through specific receptors, PGE2 activates signaling cascades that converge on Cyp4f17, promoting its expression. This direct interaction exemplifies the role of prostaglandins in modulating Cyp4f17 activity. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine indirectly activates Cyp4f17 by inhibiting the PPARγ pathway. By blocking PPARγ, piperine disrupts the negative feedback loop on Cyp4f17, resulting in increased transcription. This indirect activation reveals the intricacies of cross-regulation between PPARγ and Cyp4f17. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $37.00 $113.00 | 2 | |
α-Linolenic Acid serves as a direct activator for Cyp4f17 by interacting with its substrate-binding site. Metabolism of α-linolenic acid by Cyp4f17 leads to the generation of bioactive lipids, mediating cellular responses involved in lipid metabolism and inflammatory processes. | ||||||