Cyp4f13 Activators
Cyp4f13 Activators comprise a diverse array of chemical compounds that enhance the enzymatic function of Cyp4f13 through a variety of mechanisms. Substrates such as Arachidonic Acid, Linoleic Acid, and Alpha-Linolenic Acid directly boost Cyp4f13 activity by serving as substrates for its hydroxylase functions, which are critical for the production of signaling molecules and metabolites associated with various physiological processes. Phylloquinone, another substrate, engages Cyp4f13 through its role in the modification of proteins involved in coagulation, suggesting a pathway where Cyp4f13 could be important for maintaining hemostasis. Furthermore, the metabolism of Leukotriene B4 by Cyp4f13 suggests that an increase in Leukotriene B4 levels could directly augment the enzyme's activity, thereby potentially regulating inflammatory responses.
Moreover, compounds like Montelukast and Zileuton, which modulate leukotriene signaling by acting as a receptor antagonist and a synthesis inhibitor respectively, may lead to an increased demand for Cyp4f13's metabolic activity to handle the altered leukotriene levels. Retinoic Acid's impact on gene expression includes a feedback loop that could enhance the metabolic role of Cyp4f13 in retinoid processing. Andrographolide, with its anti-inflammatory effects, may alter the production of metabolites that are substrates for Cyp4f13, suggesting an adaptive enhancement of the enzyme's activity in response to changes in inflammatory status. Additionally, Indomethacin, by inhibiting the cyclooxygenase pathway, can shunt more arachidonic acid toward Cyp4f13 metabolism, thereby promoting its function. Lastly, Perfluorooctanoic Acid, known to affect the expression of several cytochrome P450 enzymes, could potentially enhance Cyp4f13 activity by affecting the enzyme's expression or substrate availability, thus implicating it in the complex regulation of lipid metabolism and signaling pathways. Collectively, these activators contribute to the functional upregulation of Cyp4f13, demonstrating the enzyme's integral role in diverse biological processes including inflammation, coagulation, and lipid metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vitamin K1 | 84-80-0 | sc-280189 sc-280189A | 1 g 5 g | $81.00 $166.00 | ||
Phylloquinone, also known as Vitamin K1, is involved in the post-translational modification of certain proteins. It participates in the carboxylation of glutamate residues, which is necessary for the activity of some proteins. Cyp4f13 is implicated in the metabolism of vitamin K and related compounds; thus, phylloquinone may indirectly enhance Cyp4f13 activity by serving as a substrate that requires metabolic processing. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid is a polyunsaturated fatty acid that serves as the substrate for various cytochrome P450 enzymes including Cyp4f13. Its presence can enhance the enzymatic activity of Cyp4f13 by providing substrate for omega-hydroxylation, a reaction catalyzed by this enzyme. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid is another polyunsaturated fatty acid that can be metabolized by Cyp4f13. Supplying Linoleic Acid can increase the activity of Cyp4f13 by providing additional substrate for the enzyme's hydroxylase function. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
Alpha-Linolenic Acid, like other fatty acids, can be a substrate for Cyp4f13. Its metabolism by Cyp4f13 may lead to the production of signaling molecules that indirectly increase the activity of Cyp4f13 through feedback mechanisms. | ||||||
Montelukast Sodium | 151767-02-1 | sc-202231 sc-202231A sc-202231B | 10 mg 25 mg 250 mg | $51.00 $85.00 $161.00 | 5 | |
Montelukast is a leukotriene receptor antagonist that may impact the metabolism of leukotrienes by Cyp4f13. By inhibiting the receptor signaling, Montelukast could lead to an increased availability of leukotrienes for metabolism by Cyp4f13, thus enhancing its activity. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $84.00 $307.00 $369.00 $1254.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor that reduces the synthesis of leukotrienes. This could result in a compensatory increase in leukotriene metabolism by Cyp4f13, thereby enhancing the enzyme's activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 is a product of arachidonic acid metabolism. It may indirectly augment Cyp4f13 activity by increasing the availability of arachidonic acid as a substrate, as some of it is shunted away from other metabolic pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A and is known to regulate gene expression. Cyp4f13 is involved in the metabolism of retinoids; the presence of retinoic acid could enhance Cyp4f13 activity through a feedback mechanism. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Leukotriene B4 is a potent inflammatory mediator and a substrate for Cyp4f13. Increased levels of Leukotriene B4 can enhance Cyp4f13 activity by providing more substrate for the enzyme to metabolize. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide, a diterpenoid compound known for its anti-inflammatory properties, may influence Cyp4f13 activity by modifying inflammatory responses and potentially altering leukotriene and prostaglandin metabolism. | ||||||