Linoleic Acid CAS: 60-33-3
MF: C18H32O2
MW: 280.44
A fatty acid with cytotoxic activity that influences the inflammatory process.

Linoleic Acid (CAS 60-33-3)

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同义词: Telfairic Acid; 9-cis,12-cis-Octadecadienoic acid
应用; A fatty acid with cytotoxic activity that influences the inflammatory process
CAS号码: 60-33-3
纯度: ≥99%
分子量: 280.44
分子式: C18H32O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Linoleic Acid is a fatty acid that has been observed to influence the inflammatory process and regulate the functions of neutrophils. Research has demonstrated that Linoleic Acid has cytotoxic activity and induces cell apoptosis by augmenting cellular oxidant status and inducing mitochondrial dysfunction. Additionally, the compound has been shown to stimulate the growth of MDA-MB-231 cells, increase the production of thromboxanes and prostaglandins, and reduce the levels of HHT and HETE. Linoleic Acid is an activator of PPAR.


参考文献

1. Srivastava, K.C., et al. 1982. Prostaglandins Leukot Med. 9: 669-684. PMID: 6818563
2. Rose, D.P., et al. 1994. Cancer Res. 54: 6557-6562. PMID: 7987856
3. Rodrigues, H.G., et al. 2010. Lipids. 45: 809-819. PMID: 20730605
4. Lu, X., et al. 2010. Lipids Health Dis. 9: 106. PMID: 20868498

物理状态 :
Liquid
溶解度 :
Soluble in DMSO, ethanol, ether, acetone, and benzene. Insoluble in water.
保存 :
Store at -20° C
熔点 :
-5° C (lit.)
沸点 :
229-230° C (lit.) at 16 mmHg
密度 :
0.90 g/mL at 25° C (lit.)
折射率 :
n20D 1.47 (lit.)
IC50 :
GPR40: EC5050 = 0.54 µM; COX1: IC50 = 13 µM; LO1: IC50 = 1 µM (soybean)
pK值 :
pKa: 4.77
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
RTECS :
RF9990000
PubChem CID :
5280450
默克索引 :
14: 5505
MDL 号码 :
MFCD00064241
EC号码 :
200-470-9
Beilstein 注册 :
1727101
SMILES :
CCCCCC=CCC=CCCCCCCCC(=O)O

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引用1 - 33

PMID: # 28973946  Lopez, MS. et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: 11223-11228.

PMID: # 15170673  Kohno, H. et al. 2004. Int. J. Cancer. 110: 896-901.

PMID: # 32157714  J. Food Biochem. e13177.

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