Cyp3a44 Activators
Cyp3a44, a pivotal cytochrome P450 enzyme, plays a crucial role in xenobiotic metabolism, exhibiting diverse functions predicted to include aromatase and iron ion binding activities. Positioned in the endoplasmic reticulum and membrane, Cyp3a44 is strategically located for its involvement in critical cellular processes. Its predicted role in response to bacteria implies potential connections with immune regulation, further highlighting the multifaceted nature of its functions. Additionally, the predicted localization within organelles crucial for drug metabolism underscores its significance in the biotransformation of diverse pharmaceuticals and environmental chemicals.
The activation of Cyp3a44 involves an intricate network of chemical activators that modulate specific signaling pathways, ultimately influencing the expression and activity of this enzyme. These activators act through various mechanisms, including the induction of oxidative stress, modulation of nuclear receptors such as CAR, PXR, Nrf2, and hormonal regulation via glucocorticoid receptors. Each chemical activator establishes a direct link between exposure and the upregulation of Cyp3a44, underscoring the specificity of the regulatory mechanisms involved. Furthermore, the activation pathways reveal a broader connection to cellular functions beyond xenobiotic metabolism. Signaling pathways such as AhR, PPARα, PPARγ, RXRα, FXR, RORα, LXRα, and LRH-1 are implicated in the activation of Cyp3a44, emphasizing its integration into intricate networks governing lipid homeostasis, circadian rhythm modulation, and response to environmental stimuli. The diversity of these pathways highlights the complexity of Cyp3a44 regulation, positioning it as a key player in cellular responses to chemical exposures and suggesting its involvement in broader physiological processes. Understanding the intricate mechanisms of Cyp3a44 activation is crucial for unraveling its role in the cellular landscape, shedding light on its diverse functions in the context of chemical exposures and cellular responses to environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $29.00 $96.00 | 1 | |
BHA activates Cyp3a44 by inducing oxidative stress via reactive oxygen species (ROS). It stimulates Nrf2, a transcription factor regulating antioxidant response element (ARE)-dependent gene expression. This establishes a link between BHA exposure, oxidative stress, and the upregulation of Cyp3a44. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin activates Cyp3a44 by interacting with the pregnane X receptor (PXR), leading to increased expression and enhanced enzymatic activity. This direct activation pathway establishes a connection between rifampicin exposure, PXR-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone serves as a potent activator of Cyp3a44 by modulating glucocorticoid receptor (GR) signaling, inducing the transcription of Cyp3a44 and promoting its expression and metabolic activity. This underscores the importance of hormonal regulation in modulating the expression of this cytochrome P450 enzyme. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole activates Cyp3a44 by influencing the aryl hydrocarbon receptor (AhR) signaling pathway. Through AhR activation, omeprazole induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a connection between omeprazole exposure, AhR-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine acts as an activator of Cyp3a44 by modulating the nuclear receptor farnesoid X receptor (FXR) signaling, inducing the transcription of Cyp3a44 and leading to increased expression and enhanced enzymatic activity. This establishes a link between amodiaquine exposure, FXR-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic Acid activates Cyp3a44 by influencing the peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathway. Through PPARγ activation, ellagic acid induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a connection between ellagic acid exposure, PPARγ-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone serves as an activator of Cyp3a44 by modulating the retinoid X receptor alpha (RXRα) signaling pathway. Upon binding to RXRα, troglitazone induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a link between troglitazone exposure, RXRα-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Carbamazepine acts as a potent activator of Cyp3a44 through the modulation of the retinoic acid receptor-related orphan receptor alpha (RORα) signaling pathway. By binding to RORα, carbamazepine induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a connection between carbamazepine exposure, RORα-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates Cyp3a44 by modulating the liver X receptor alpha (LXRα) signaling pathway. Through LXRα activation, quercetin induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a connection between quercetin exposure, LXRα-mediated signaling, and the upregulation of Cyp3a44. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $168.00 | 3 | |
Efavirenz acts as an activator of Cyp3a44 through the modulation of the liver receptor homolog-1 (LRH-1) signaling pathway. By binding to LRH-1, efavirenz induces the transcription of Cyp3a44, leading to increased expression and enhanced enzymatic activity. This establishes a link between efavirenz exposure, LRH-1-mediated signaling, and the upregulation of Cyp3a44. | ||||||