Troglitazone CAS: 97322-87-7
MF: C24H27NO5S
MW: 441.5
A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent.

Troglitazone (CAS 97322-87-7)

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Aplicação A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent
Numero VAT: 97322-87-7
Privada: ≥98%
Peso Molecular: 441.5
Separar por Funcao: C24H27NO5S
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Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells.


Referencias

1. Tsubouchi, Y., et al. 2000. Biochem. Biophys. Res. Commun. 270: 400-405. PMID: 10753637
2. Okura, T., et al. 2000. Eur. J. Pharmacol. 407: 227-235. PMID: 11068018
3. Fujiwara, T., et al. 2000. Life Sci. 67: 2405-2416. PMID: 11065164
4. Aljada, A., et al. 2001. J. Clin. Endocrinol. Metab. 86: 3250-3256. PMID: 11443197
5. Berger, J., et al. 2002. Annu. Rev. Med. 53: 409-435. PMID: 11818483
6. Yoshizawa, K., et al. 2002. Cancer. 95: 2243-2251. PMID: 12412180

Estado físico :
Solid
envie :
Soluble in ethanol (>25 mg/ml) at 50° C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25° C.
Manutencao :
Store at -20° C
Ponto de fusão :
312.54° C (Predicted)
Ponto de fervura :
~657.0° C at 760 mmHg (Predicted)
Densidade :
~1.3 g/cm3 (Predicted)
Indice de produtos :
n20D 1.61 (Predicted)
IC50 :
Stimulatin PPARγg glucose transport: EC5050 = 1 µM (adipocytes); PPARγ: EC5050 = 780 nM (murine); PPARγ: EC5050 = 555 nM (human); Induces cell cycle arrest and apoptosis: EC5050 = 10 µM (cancer cell lines); Monoamine oxidase B: IC50 = 2.07 µM (human)
Data ki :
Peroxisome proliferator-activated receptor gamma: Ki= 3.8 µM (human)
Valores de pK :
pKa: 6.35 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
2
RTECS :
XJ5813130
PubChem CID :
5591
Indice de produtos :
14: 9769
Numero de FAX :
MFCD00878416
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

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Troglitazone  Citacoes dos Produtos

Visualizar com outras pessoas usaram Troglitazone. Clique em PubMed para ver .

Citações 1 para 5 de 5 total

PMID: # 31416829  2019. Biochem. J. 476: 2427-2447.

PMID: # 26313919  Myneni, VD. et al. 2015. Cell death & disease. 6: e1868.

PMID: # 24910239  Penner, N. et al. 2014. Drug Metab Lett. 8: 36-42.

PMID: # 22981620  Kim, JA. et al. 2012. Toxicology letters. 214: 175-81.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Citações 1 para 5 de 5 total
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