cubitus interruptus Activators
Cubitus Interruptus activators are primarily focused on modulating the Hedgehog signaling pathway, which is essential for the proper functioning and activation of Ci. The Hedgehog pathway, a key signaling mechanism in embryonic development and cell differentiation, involves several components including Patched (Ptch), Smoothened (Smo), and the Gli family of transcription factors. Ci, the Drosophila counterpart of Gli proteins, is regulated through similar mechanisms.
The chemicals listed above, such as Cyclopamine and Vismodegib, function by inhibiting Smo, a central component of the Hedgehog pathway. This inhibition is crucial because Smo's activity is normally suppressed by Ptch. In the absence of Hedgehog ligands, Ptch inhibits Smo, leading to the processing of Ci into a repressor form. However, when these inhibitors are introduced, they prevent Smo activation, which in turn allows Ci to remain in its full-length, active form. This process is central to the indirect activation of Ci.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT-61 targets Gli proteins, downstream effectors of the Hedgehog pathway. By inhibiting Gli, it indirectly affects Ci activation, as Gli proteins are part of the regulatory feedback mechanisms in the pathway. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine is a small molecule that activates the Hedgehog pathway by targeting Smo. This activation can indirectly lead to the stabilization and activation of Ci. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Sonidegib is another Smo inhibitor that, through its action on the Hedgehog pathway, indirectly leads to the activation of Ci. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $166.00 $421.00 | 27 | |
SAG is a chlorobenzothiophene that directly activates Smo, leading to downstream effects in the Hedgehog pathway, including the activation of Ci. | ||||||
Robotnikinin | 1132653-79-2 | sc-396554 | 1 mg | $650.00 | 1 | |
Robotnikinin is a small molecule designed to disrupt Hedgehog signaling. Its unique mechanism of action can influence Ci activity indirectly by modulating pathway dynamics. | ||||||