CTPS2 Inhibitors
CTPS2 inhibitors encompass a variety of chemical compounds that indirectly mitigate the activity of this protein by manipulating the nucleotide synthesis pathways and cellular metabolite levels. For instance, through the inhibition of enzymes that are crucial for the utilization of glutamine, a vital nitrogen donor in the CTP synthesis process, the function of CTPS2 is indirectly hampered due to the reduced availability of this substrate. This is also exemplified by compounds that act as glutamine antimetabolites, which by thwarting glutamine-dependent enzymes, diminish the accessible glutamine, thereby inadvertently restraining CTPS2's catalytic activity. Similarly, the meddling with the de novo synthesis of pyrimidines by targeting enzymes like dihydroorotate dehydrogenase results in a deficit of pyrimidine nucleotides, which in turn invokes a feedback inhibition that curtails CTPS2 activity. Furthermore, agents that inhibit inosine monophosphate dehydrogenase and ribonucleotide reductase disrupt the homeostasis of nucleotide pools, influencing the regulatory feedback mechanisms that CTPS2 is subject to, leading to its indirect inhibition. These disruptions manifest as imbalances in the levels of GTP, dGTP, and other deoxyribonucleotides, which can significantly impede CTPS2's function within the cell.
Additionally, the indirect inhibition of CTPS2 can be accomplished by the utilization of compounds that affect the synthesis of thymidylate and purine nucleotides, as such disturbances can trigger a cascade of feedback inhibitions that affect CTPS2's activity. The incorporation of nucleoside analogs into the nucleotide synthesis pathways can also achieve this inhibition, as they can lead to dCTP pool depletion or accumulation, depending on their mechanism of action, which then influences CTPS2 through feedback regulatory processes. Notably, glutamine antagonists serve to indirectly inhibit CTPS2 by impairing the availability of glutamine for CTP production from UTP, demonstrating the intricate interplay between metabolic pathways and the regulation of enzymatic activities.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
This compound is a glutamine analog which inhibits enzymes that utilize glutamine as a substrate. CTPS2 relies on glutamine as a nitrogen donor in the synthesis of CTP from UTP. Inhibition of glutamine-utilizing enzymes by Acivicin can therefore indirectly inhibit the catalytic activity of CTPS2. | ||||||
6-Diazo-5-oxo-L-norleucine | 157-03-9 | sc-227078 sc-227078A sc-227078B sc-227078C | 5 mg 25 mg 100 mg 250 mg | $88.00 $291.00 $926.00 $2195.00 | ||
A glutamine antimetabolite that inhibits glutamine-dependent enzymes. Since CTPS2 uses glutamine as a substrate, this compound's inhibition of glutamine metabolism can lead to reduced availability of glutamine, thus indirectly inhibiting CTPS2 activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
This compound is an inosine monophosphate dehydrogenase inhibitor which leads to decreased levels of GTP and subsequently dGTP. This imbalance in ribonucleotide levels can indirectly inhibit CTPS2 by disrupting the nucleotide feedback inhibition mechanism. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a nucleoside analog that inhibits inosine monophosphate dehydrogenase, leading to a depletion of GTP pools. This can indirectly affect CTPS2 by altering the regulatory balance of ribonucleotides, which is essential for its function. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, decreasing the pool of deoxyribonucleotides, including dCTP. This can indirectly inhibit CTPS2 by enhancing the feedback inhibition due to increased levels of dCTP, which can bind and inhibit CTPS2. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide metabolite A77 1726 inhibits dihydroorotate dehydrogenase, leading to pyrimidine starvation. The resulting decrease in pyrimidine nucleotides can indirectly inhibit CTPS2 through feedback mechanisms that control nucleotide synthesis. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Allopurinol is a xanthine oxidase inhibitor which can lead to increased levels of AMP and GMP, thereby potentially causing an imbalance in nucleotide pools. This disrupts the feedback regulatory mechanisms that CTPS2 is subjected to, thus indirectly inhibiting its activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, affecting the synthesis of thymidylate and purine nucleotides. This disruption can lead to an imbalance in de novo nucleotide pools, which may result in indirect inhibition of CTPS2 through feedback inhibition. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Inhibits thymidylate synthase, leading to thymineless death and disruption of nucleotide synthesis. This can indirectly inhibit CTPS2 by altering the balance of nucleotides and engaging feedback inhibition mechanisms. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that inhibits ribonucleotide reductase, leading to a decrease in deoxynucleotide triphosphate pools. This can indirectly inhibit CTPS2 by increasing the levels of dCTP, which in turn can inhibit CTPS2 due to feedback regulation. | ||||||