CTAGE2 Activators

CTAGE2 Activators are chemicals that can enhance the functional activity of CTAGE2 through specific signaling pathways that CTAGE2 is directly involved in. All the chemicals listed here either activate SIRT1, inhibit the PI3K/AKT pathway, inhibit the mTOR pathway, or inhibit the MAPK pathway, which can lead to the activation of FOXO3a and subsequently enhance the transcription of CTAGE2. Resveratrol is known to activate SIRT1, which can deacetylate FOXO3a.

Deacetylated FOXO3a can translocate to the nucleus and activate the transcription of CTAGE2. Berberine and Metformin can inactivate the mTOR pathway or directly activate AMPK, leading to the activation of FOXO3a, and subsequently enhance the transcription of CTAGE2. AICAR also activates AMPK, leading to FOXO3a activation and subsequent enhancement of CTAGE2 transcription. On the other hand, chemicals like Quercetin, Wogonin, Curcumin, Genistein, EGCG, LY294002, PD98059, and U0126 inhibit the PI3K/AKT pathway or the MAPK pathway, which enhances FOXO3a activity. Activated FOXO3a can promote the transcription of CTAGE2.