CREB-2 Inhibitors
CREB-2 inhibitors belong to a chemical class that has garnered significant interest in the realm of molecular research due to their distinct properties and impacts on cellular processes. These inhibitors are designed to interact with and modulate the activity of CREB-2, a transcription factor that plays a crucial role in gene expression regulation within cells. CREB-2, also known as ATF-4, is a member of the cAMP response element-binding (CREB) protein family. It operates as a transcriptional repressor, binding to specific DNA sequences known as CRE sites to suppress the expression of target genes. CREB-2's involvement is particularly noteworthy in contexts where cellular responses to stress, growth factors, and environmental changes are mediated.
CREB-2 inhibitors are characterized by their ability to disrupt the binding of CREB-2 to CRE sites, thereby modulating the regulatory machinery that governs gene expression. These inhibitors often function by competitively binding to CREB-2 or altering its conformation, preventing its effective interaction with DNA. By doing so, they may exert an influence on the overall transcriptional landscape of the cell, leading to alterations in various biological processes. The elucidation of CREB-2 inhibitors' mechanisms of action holds substantial promise for uncovering insights into the intricacies of gene regulation and cellular responses to diverse stimuli. Ongoing research seeks to unravel the structural attributes and biochemical interactions that underlie the effectiveness of these inhibitors, aiming to pave the way for a more comprehensive understanding of CREB-2's role in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K252a is a natural product that inhibits CREB-2 by interfering with its kinase activity, thereby preventing its phosphorylation and inactivation of CREB-mediated gene expression. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H89 is a selective protein kinase A (PKA) inhibitor. By blocking PKA activity, it indirectly inhibits CREB-2 phosphorylation, thus reducing its inhibitory effect on CREB-mediated transcription. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT5720 is another PKA inhibitor that indirectly counteracts CREB-2 inhibition by preventing CREB phosphorylation, allowing for enhanced CREB-dependent gene expression. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a phosphodiesterase-4 (PDE4) inhibitor. By increasing cAMP levels through inhibition of cAMP hydrolysis, it leads to reduced CREB-2 activity and increased CREB-dependent gene transcription. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor. It indirectly modulates CREB-2 activity by disrupting CaMKII-mediated phosphorylation events that affect CREB function. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro-31-8220 inhibits various protein kinases, including PKA and PKC. By inhibiting these kinases, it indirectly affects CREB-2 phosphorylation and its inhibitory impact on CREB activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a PKC inhibitor that indirectly influences CREB-2 activity by preventing PKC-mediated phosphorylation events that regulate CREB function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 is another PKC inhibitor that indirectly modulates CREB-2 function by inhibiting PKC-mediated phosphorylation of CREB and associated signaling pathways. | ||||||
Methiothepin mesylate salt | 74611-28-2 | sc-253005 | 100 mg | $138.00 | 1 | |
Methiothepin is a serotonin receptor antagonist that indirectly impacts CREB-2 activity by influencing serotonergic signaling pathways that can regulate CREB function. | ||||||
Arcyriaflavin A | 118458-54-1 | sc-202470 sc-202470A sc-202470B | 1 mg 10 mg 100 mg | $152.00 $292.00 $1796.00 | 4 | |
Arcyriaflavin A is a natural product that inhibits protein phosphatases, leading to increased phosphorylation of CREB and reduced inhibitory effects of CREB-2 on CREB-mediated gene expression. | ||||||