CRB3 Activators
CRB3 activators represent a diverse class of compounds designed to modulate the activity of Crumbs homolog 3 (CRB3), a transmembrane protein crucial for cell polarity and adhesion. Among these activators, Nobiletin, Betulinic acid, 3-Deazaneplanocin A (DZNep), Wogonin, Amlexanox, Butein, Amphotericin B, Chrysin, Rapamycin, Resveratrol, Forskolin, and Withaferin A have been identified as potential agents to influence CRB3 activity. These activators act through various mechanisms, providing valuable insights into the regulation of CRB3-mediated cellular processes. Nobiletin and Wogonin, both flavonoids, directly activate CRB3 by modulating the PI3K/Akt signaling pathway, enhancing Akt phosphorylation and downstream events associated with CRB3 activation. Betulinic acid, on the other hand, engages with the Hippo signaling pathway to directly stimulate CRB3 activity, emphasizing the importance of this intricate network in governing CRB3 function. 3-Deazaneplanocin A (DZNep), an epigenetic modulator, indirectly activates CRB3 by influencing the methylation status of relevant genes, providing an indirect approach to modulate CRB3 activity through epigenetic regulation. Amlexanox, an anti-inflammatory agent, indirectly activates CRB3 by modulating cellular inflammatory responses, contributing to the regulatory network governing CRB3 function.
Butein and Chrysin, both flavonoids, directly activate CRB3 by modulating the PI3K/Akt signaling pathway, providing a targeted approach to influence CRB3 through direct activation of this pathway. Amphotericin B, an antifungal agent, indirectly activates CRB3 by modulating cellular stress responses, offering an indirect approach to modulate CRB3 activity through stress-related pathways. Rapamycin, an mTOR inhibitor, indirectly activates CRB3 by disrupting the mTOR pathway, relieving negative feedback on CRB3 and leading to its activation. This compound provides an indirect approach to influence CRB3 activity by targeting the intricate mTOR pathway. Resveratrol and Forskolin, compounds known for their diverse cellular effects, directly activate CRB3 by modulating the PI3K/Akt signaling pathway and cAMP signaling, respectively, contributing to the regulatory network governing CRB3 function. Withaferin A, a steroidal lactone, directly activates CRB3 by engaging with the Hippo signaling pathway, emphasizing the critical role of the Hippo pathway in the regulation of CRB3-mediated cellular processes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Nobiletin, a flavonoid, activates CRB3 directly by modulating the PI3K/Akt signaling pathway. By promoting Akt phosphorylation, Nobiletin enhances the downstream events that lead to CRB3 activation. This compound provides a targeted approach to influence CRB3 through the activation of the PI3K/Akt pathway, contributing to cellular processes governed by CRB3 activity. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid, a triterpenoid, activates CRB3 directly by engaging with the Hippo signaling pathway. Through modulation of key components such as MST1/2 or YAP/TAZ, Betulinic acid stimulates the signaling cascade leading to CRB3 activation. This compound offers a focused means to influence CRB3 by directly targeting the intricate network of the Hippo pathway that governs CRB3 activity. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin, a flavonoid, activates CRB3 directly by modulating the PI3K/Akt signaling pathway. Through the enhancement of Akt phosphorylation, Wogonin facilitates downstream events leading to CRB3 activation. This compound offers a targeted approach to influence CRB3 through the activation of the PI3K/Akt pathway, contributing to cellular processes governed by CRB3 activity. | ||||||
Amlexanox | 68302-57-8 | sc-217630 | 10 mg | $160.00 | 2 | |
Amlexanox, an anti-inflammatory agent, indirectly activates CRB3 by modulating cellular inflammatory responses. Through its impact on inflammation-related pathways, Amlexanox indirectly influences the activation status of CRB3. This compound provides an indirect approach to modulate CRB3 activity by altering cellular responses associated with inflammation, contributing to the regulatory network governing CRB3 function. | ||||||
Butein | 487-52-5 | sc-202510 sc-202510A | 5 mg 50 mg | $172.00 $306.00 | 8 | |
Butein, a chalcone derivative, activates CRB3 directly by engaging with the PI3K/Akt signaling pathway. By promoting Akt phosphorylation, Butein enhances downstream events that lead to CRB3 activation. This compound offers a focused means to influence CRB3 through the direct activation of the PI3K/Akt pathway, contributing to cellular processes governed by CRB3 activity. | ||||||
Amphotericin B | 1397-89-3 | sc-202462 sc-202462A sc-202462B | 100 mg 500 mg 1 g | $69.00 $139.00 $219.00 | 10 | |
Amphotericin B, an antifungal agent, indirectly activates CRB3 by modulating cellular stress responses. Through its impact on stress-related pathways, Amphotericin B indirectly influences the activation status of CRB3. This compound provides an indirect approach to modulate CRB3 activity by altering cellular responses associated with stress, contributing to the regulatory network governing CRB3 function. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin, a natural flavonoid, activates CRB3 directly by modulating the PI3K/Akt signaling pathway. Through the enhancement of Akt phosphorylation, Chrysin facilitates downstream events that lead to CRB3 activation. This compound offers a targeted approach to influence CRB3 through the direct activation of the PI3K/Akt pathway, contributing to cellular processes governed by CRB3 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly activates CRB3 by modulating the mTOR pathway. Through the inhibition of mTOR, Rapamycin relieves negative feedback on CRB3, leading to its activation. This compound provides an indirect approach to influence CRB3 activity by disrupting the mTOR pathway, contributing to the regulatory network governing CRB3 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, activates CRB3 directly by modulating the PI3K/Akt signaling pathway. Through the enhancement of Akt phosphorylation, Resveratrol facilitates downstream events that lead to CRB3 activation. This compound offers a targeted approach to influence CRB3 through the direct activation of the PI3K/Akt pathway, contributing to cellular processes governed by CRB3 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an adenylate cyclase activator, indirectly activates CRB3 by modulating cAMP signaling. Through its impact on cAMP levels, Forskolin influences downstream events that lead to CRB3 activation. This compound provides an indirect approach to modulate CRB3 activity by affecting the cAMP signaling pathway, contributing to the regulatory network governing CRB3 function. | ||||||