Date published: 2025-10-21

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Cot Inhibitors

Cot inhibitors represent a specialized chemical class meticulously engineered to selectively target the protein kinase Cot (Cancer Osaka Thyroid), also known as Tpl2 (Tumor progression locus 2). Cot plays a pivotal role in cellular signaling pathways, particularly those intricately connected to inflammatory responses and immune modulation. The inhibitors within this class are intricately designed to perturb the catalytic activity of Cot, a kinase embedded in diverse signaling cascades, including those activated by cytokines and growth factors. The scientific pursuit of targeting Cot with these inhibitors is rooted in the aspiration to unravel the complex role of this kinase in orchestrating immune responses and inflammation. The deliberate inhibition of Cot by this class of compounds is poised to offer a nuanced understanding of the molecular mechanisms governing these processes. The Cot inhibitors hold the ability to elucidate how Cot intricately contributes to the intricate tapestry of cellular signaling networks, paving the way for a deeper comprehension of the regulatory dynamics that underlie immune and inflammatory responses. However, the comprehensive exploration of the broader implications and applications of Cot inhibitors remains contingent upon ongoing and meticulous research endeavors to unravel the multifaceted roles of Cot in cellular signaling.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tpl2 Kinase Inhibitor Inhibitor

871307-18-5sc-204351
1 mg
$250.00
6
(1)

Tpl2 Kinase Inhibitor is a selective modulator of Tpl2 kinase activity, characterized by its ability to disrupt specific protein-protein interactions within signaling cascades. This compound exhibits unique binding affinity, stabilizing an inactive conformation of the kinase, which alters downstream signaling pathways. Its kinetic profile reveals a competitive inhibition mechanism, providing insights into the regulatory networks influenced by Tpl2, and highlighting its role in cellular responses.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$26.00
$50.00
$99.00
$150.00
$1887.00
40
(1)

Luteolin, a flavonoid compound, exhibits remarkable interactions with various cellular targets, influencing multiple signaling pathways. Its unique ability to modulate enzyme activity stems from its capacity to form hydrogen bonds and π-π stacking interactions with key residues in target proteins. This results in altered reaction kinetics, enhancing or inhibiting enzymatic functions. Additionally, Luteolin's antioxidant properties contribute to its role in cellular homeostasis, impacting redox-sensitive pathways.

3′,4′,7-Trihydroxyisoflavone

485-63-2sc-206722
200 mg
$295.00
1
(1)

3',4',7-Trihydroxyisoflavone is a flavonoid that demonstrates significant binding affinity to specific receptors, facilitating unique molecular interactions that can influence gene expression. Its structural features allow for effective chelation of metal ions, which can modulate oxidative stress responses. The compound's hydrophilic nature enhances solubility in biological systems, promoting its bioavailability and interaction with cellular membranes, thereby affecting permeability and transport mechanisms.