Molecular structure of Tpl2 Kinase Inhibitor, CAS Number: 871307-18-5
Tpl2 Kinase Inhibitor Inhibitor (CAS 871307-18-5)
See product citations (6)
Alternate Names:
4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
Application:
Tpl2 Kinase Inhibitor is a reversible competitive inhibitor of Tpl2 kinase
CAS Number:
871307-18-5
Purity:
≥95%
Molecular Weight:
404.83
Molecular Formula:
C21H14ClFN6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tpl2 Kinase Inhibitor is a reversible naphthyridine ATP-competitive inhibitor of the enzyme Cot (Tpl2 kinase). The enzyme is a hematopoietically expressed serine-threonine kinase responsible for regulating tumor necrosis factor-alpha, toll-like receptor, and G protein–coupled receptor signaling. Studies suggest that Cot (Tpl2 kinase) inhibitor suppresses LPS-induced (sc-3535) TNF-alpha production from primary human monocytes. In addition, Tpl2 Kinase Inhibitor causes an increase in 1,25-Dihydroxyvitamin D3 (1,25D)-induced differentiation of myeloid leukemia cells via inhibition of Cot (Tpl2 kinase).
Tpl2 Kinase Inhibitor Inhibitor (CAS 871307-18-5) References
- Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. | Watford, WT., et al. 2008. J Exp Med. 205: 2803-12. PMID: 19001140
- Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis. | Jager, J., et al. 2010. Diabetes. 59: 61-70. PMID: 19808894
- Tpl2 is a key mediator of arsenite-induced signal transduction. | Lee, KM., et al. 2009. Cancer Res. 69: 8043-9. PMID: 19808956
- Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells. | Wang, X. and Studzinski, GP. 2010. J Steroid Biochem Mol Biol. 121: 395-8. PMID: 20227498
- Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells. | Hirata, K., et al. 2010. Biol Pharm Bull. 33: 1233-7. PMID: 20606319
- Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3). | Wang, X., et al. 2010. Cell Cycle. 9: 4542-51. PMID: 21084834
- Interleukin-17 induces AP-1 activity and cellular transformation via upregulation of tumor progression locus 2 activity. | Kim, G., et al. 2013. Carcinogenesis. 34: 341-50. PMID: 23125217
- Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice. | Kyrmizi, I., et al. 2013. J Leukoc Biol. 94: 751-7. PMID: 23898046
- Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. | Lee, HW., et al. 2013. Mol Cancer Res. 11: 1375-86. PMID: 23982215
- Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages. | Ceppo, F., et al. 2014. Endocrinology. 155: 951-64. PMID: 24424060
- The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions. | Berthou, F., et al. 2015. Mol Endocrinol. 29: 1025-36. PMID: 26020725
- Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis. | Choi, Y., et al. 2019. Nat Microbiol. 4: 429-437. PMID: 30617349
- Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) mediates the LH-induced stimulation of progesterone synthesis in the porcine corpus luteum. | Zhang, D., et al. 2019. Reprod Fertil Dev. 31: 1444-1456. PMID: 31039922
Inhibitor of:
Cot.Activator of:
Akt1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tpl2 Kinase Inhibitor, 1 mg | sc-204351 | 1 mg | $250.00 |