COL18A1 Activators

The chemical class of COL18A1 Activators encompasses various compounds that can indirectly stimulate or modulate the synthesis and stability of Collagen alpha-1(XVIII) chain, a key component of the extracellular matrix with roles in angiogenesis and tumor suppression. This class includes essential nutrients and vitamins, like Ascorbic Acid (Vitamin C), which is crucial for collagen synthesis, and Retinoic Acid, known for its role in skin health and influence on extracellular matrix composition. The inclusion of copper sulfate highlights the importance of cofactors in collagen synthesis and crosslinking.

Additionally, this class incorporates phytochemicals and natural compounds with antioxidant properties, such as Genistein, Epigallocatechin Gallate (EGCG), Curcumin, Tannic Acid, Ellagic Acid, and Resveratrol. These compounds, through their various effects on cellular pathways, can potentially enhance the synthesis and stability of COL18A1. The role of essential amino acids like Lysine, Proline, and Glycine is also emphasized, as they are integral to collagen structure and stability, potentially affecting COL18A1 production.