COL18A1 Inhibitors
COL18A1 Inhibitors consist of various compounds that can suppress or modulate the synthesis and stability of Collagen alpha-1(XVIII) chain. This class includes specific inhibitors like β-Aminopropionitrile (BAPN) that directly target enzymes involved in collagen crosslinking, thereby influencing COL18A1 synthesis. Penicillamine and Disulfiram are known to impact collagen crosslinking and metabolism, affecting COL18A1. Pharmacological agents such as Prednisolone and Glucosamine Sulfate influence collagen metabolism, while Colchicine, by affecting microtubule dynamics, can indirectly impact collagen synthesis.
Natural compounds like Epigallocatechin Gallate (EGCG) and Emodin can modulate collagen metabolism, inhibiting COL18A1 synthesis. Exposure to heavy metals, represented by Lead Acetate, disrupts various cellular processes, including collagen synthesis. Antibiotics like Doxycycline, known for their MMP inhibitory effects, and chemotherapy agents such as Cyclophosphamide and Methotrexate, with their impact on cellular replication and protein synthesis, also contribute to the regulation of COL18A1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
A lathyrogen that inhibits lysyl oxidase, an enzyme crucial for collagen crosslinking. By inhibiting this enzyme, BAPN can indirectly affect collagen synthesis and stability, potentially influencing COL18A1. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Can bind to pyridoxine (vitamin B6) and decrease collagen crosslinking, potentially affecting COL18A1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An inhibitor of aldehyde dehydrogenase that can affect collagen crosslinking, potentially influencing COL18A1 synthesis. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $84.00 $253.00 | 2 | |
A corticosteroid that affects collagen metabolism and wound healing; long-term use may potentially inhibit collagen synthesis, including COL18A1. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Affects microtubule formation, potentially influencing cellular processes including collagen synthesis, thereby inhibiting COL18A1. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
An anthraquinone derivative, known to modulate collagen metabolism and potentially inhibit COL18A1 synthesis. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
A heavy metal compound that disrupts various cellular processes, including collagen synthesis, potentially leading to the inhibition of COL18A1. | ||||||
Doxycycline Hyclate | 24390-14-5 | sc-204734B sc-204734 sc-204734A sc-204734C | 100 mg 1 g 5 g 25 g | $27.00 $50.00 $105.00 $194.00 | 25 | |
A tetracycline antibiotic known to inhibit matrix metalloproteinases and affect collagen metabolism, potentially influencing COL18A1 levels. | ||||||
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $90.00 $146.00 $469.00 $791.00 | 18 | |
An alkylating agent used in chemotherapy that affects DNA synthesis and cellular replication, thereby potentially influencing the synthesis of proteins like COL18A1. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
A chemotherapy and immunosuppressant drug that can impact cell proliferation and protein synthesis, potentially influencing COL18A1 synthesis. | ||||||