COL16A1 Inhibitors
COL16A1 inhibitors pertain to a class of chemical compounds specifically designed to impede the action or synthesis of the protein encoded by the COL16A1 gene. This gene is responsible for the production of collagen type XVI, a component of the extracellular matrix (ECM). Collagens are a large family of proteins that play a critical role in the structural integrity of various tissues within the body and are involved in a myriad of cellular functions, including cell adhesion, migration, and the maintenance of tissue architecture. The inhibition of COL16A1 can, therefore, influence the behavior of cells and the composition of the ECM by altering the levels of collagen type XVI present.
COL16A1 inhibitors interact with the biochemical pathway of collagen type XVI at various potential points. This could involve either the direct inhibition of the protein's function by preventing its interaction with other ECM components or cell surface receptors, or by inhibiting the processes that lead to its synthesis, such as transcription or translation. The design of these inhibitors is often based on the understanding of the protein's structure, its post-translational modifications, and its interactions within the ECM.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $30.00 $101.00 $277.00 $959.00 | 2 | |
Tranilast can inhibit collagen synthesis by fibroblasts, which may reduce COL16A1 production. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1740.00 | ||
Halofuginone inhibits the synthesis of type I collagen; it may also reduce the synthesis of other collagens, including COL16A1, by a similar mechanism. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Required for collagen synthesis; its reduction leads to decreased hydroxylation of proline and lysine, limiting proper collagen fiber formation, including COL16A1. | ||||||
Protocatechuic acid | 99-50-3 | sc-205818 sc-205818A | 25 g 50 g | $126.00 $255.00 | 9 | |
This compound can inhibit prolyl 4-hydroxylase, which is necessary for collagen maturation; by doing so, it may affect the stability and secretion of COL16A1. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $45.00 $94.00 | ||
Can bind to copper, an essential cofactor for lysyl oxidase, which is required for collagen crosslinking; by chelating copper, it may prevent proper COL16A1 crosslinking and fibril formation. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $102.00 | ||
A lathyrogen that inhibits lysyl oxidase, preventing collagen crosslinking and affecting COL16A1's integration into the extracellular matrix. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
Has shown effects on downregulating collagen gene expression and can inhibit collagen synthesis, which may include COL16A1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can alter intracellular signaling pathways, potentially reducing the expression of collagen genes including COL16A1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Inhibits lysyl oxidase by chelating copper, potentially affecting the maturation and function of COL16A1 within the extracellular matrix. | ||||||