COG3 Activators
The chemical class of COG3 activators primarily consists of compounds that indirectly influence the COG3 protein by targeting cellular processes and structures closely related to the function of the COG complex. These activators do not bind directly to COG3 but modulate the Golgi apparatus's environment, trafficking mechanisms, and cellular signaling pathways, which are critical for the proper functioning of the COG complex.
Brefeldin A, Monensin, and Golgicide A, for instance, target various aspects of Golgi function. Brefeldin A disrupts the Golgi structure by inhibiting ARF proteins, Monensin alters intracellular pH levels, and Golgicide A inhibits GBF1, a factor involved in Golgi maintenance. These disruptions can indirectly influence COG3 activities within the Golgi. On the other hand, compounds like Forskolin, Genistein, and Tunicamycin affect broader cellular processes that may impact COG3 function. Forskolin elevates cAMP levels, influencing numerous signaling pathways. Genistein, as a tyrosine kinase inhibitor, can modulate signaling cascades that intersect with COG3's functional pathways. Tunicamycin inhibits N-linked glycosylation, a process central to Golgi function, thus indirectly affecting COG3 activities.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Known to elevate cAMP levels, Forskolin can modulate various signaling pathways that may indirectly impact the function of the COG complex. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
This inhibitor of N-WASP, involved in actin polymerization, can indirectly affect Golgi dynamics and potentially the COG complex's function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
By stabilizing microtubules, Paclitaxel can indirectly affect the positioning and function of the Golgi apparatus and COG complex. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a broad-spectrum tyrosine kinase inhibitor, Genistein may indirectly affect signaling pathways relevant to COG complex functions. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
This inhibitor of N-linked glycosylation can indirectly affect COG3 by altering the glycosylation status of proteins within the Golgi. | ||||||