CLEC-2G Activators
CLEC-2G, a pivotal player in cellular regulation, exhibits a distinct natural killer cell lectin-like receptor binding activity, suggesting its crucial role in immune response modulation. This gene is predominantly situated in the cell surface and endoplasmic reticulum, with anticipated activity on the external side of the plasma membrane. The orthologous relationship to human CLEC2D implies functional conservation, emphasizing its potential involvement in the negative regulation of osteoclast differentiation. This positioning and function underscore CLEC-2G as a multifaceted actor in cellular processes, contributing to immune surveillance and response coordination.
The activation of CLEC-2G is orchestrated through a complex interplay of biochemical events. Diverse activators, including signaling molecules and receptor interactions, intricately modulate CLEC-2G function. These mechanisms include S1P receptor binding, protease-activated receptor (PAR) signaling, inhibition of PKC, protein phosphatase inhibition, TP receptor activation, calcium influx induction, and P2Y1 and P2Y12 receptor binding. These events culminate in the modulation of CLEC-2G's natural killer cell lectin-like receptor binding activity, highlighting the intricacy of the cellular processes involved. Indirect activation through GPVI binding and ERK/MAPK pathway modulation further expands the repertoire of CLEC-2G's regulatory influences. This sophisticated network of activation mechanisms positions CLEC-2G as a key orchestrator in cellular processes, contributing to immune response modulation and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Direct activator of CLEC-2G by binding to S1P receptors. Fingolimod modulates the S1P signaling pathway, positively influencing CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2G function by activating the S1P receptor-dependent pathway. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Activates CLEC-2G through protease-activated receptor (PAR) signaling. Thrombin induces PAR signaling, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2G activation by modulating the PAR-dependent pathway. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Direct activator of CLEC-2G by inhibiting PKC. Bisindolylmaleimide I inhibits PKC, enhancing CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2G function by modulating PKC-dependent pathways and influencing cellular processes associated with CLEC-2G. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Activates CLEC-2G through protein phosphatase inhibition. Calyculin A inhibits protein phosphatases, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2G activation by modulating protein phosphatase-dependent pathways. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $245.00 $1301.00 | 40 | |
Direct activator of CLEC-2G through TP receptor activation. U46619 activates TP receptors, positively influencing CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2G function by modulating TP receptor-dependent pathways and influencing cellular processes associated with CLEC-2G. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Direct activator of CLEC-2G by activating PKC. PMA activates PKC, enhancing CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2G function by modulating PKC-dependent pathways and influencing cellular processes associated with CLEC-2G. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Direct activator of CLEC-2G through S1P receptor binding. S1P binds to its receptor, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2G activation by modulating the S1P receptor-dependent pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Direct activator of CLEC-2G through calcium signaling. A23187 induces calcium influx, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2G function by modulating calcium-dependent pathways and influencing cellular processes associated with CLEC-2G. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
Activates CLEC-2G through P2Y1 and P2Y12 receptor binding. ADP binds to P2Y1 and P2Y12 receptors, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2G activation by modulating P2Y1 and P2Y12 receptor-dependent pathways. | ||||||
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Upregulates CLEC-2G through ERK/MAPK pathway activation. Nobiletin activates the ERK/MAPK pathway, positively affecting CLEC-2G's natural killer cell lectin-like receptor binding activity. This compound indirectly activates CLEC-2G by modulating the ERK/MAPK pathway and influencing cellular processes associated with CLEC-2G. | ||||||