CLEC-2F Activators
CLEC-2F, a gene predicted to enable natural killer cell lectin-like receptor binding activity, is poised at the cell surface and endoplasmic reticulum, with predicted activity on the external side of the plasma membrane. Its orthologous relationship to human CLEC2D suggests its evolutionary conservation and potential involvement in immune response modulation. The activation of CLEC-2F involves a spectrum of chemical regulators that either directly or indirectly impact its function. Fingolimod, through S1P receptor binding, directly activates CLEC-2F, influencing natural killer cell lectin-like receptor binding activity. Thrombin, a potent activator, triggers CLEC-2F via protease-activated receptor (PAR) signaling. Bisindolylmaleimide I, by inhibiting PKC, enhances CLEC-2F's receptor binding activity. Calyculin A activates CLEC-2F through protein phosphatase inhibition, and U46619, by activating TP receptors, directly influences its function. PMA, an activator of PKC, plays a direct role in CLEC-2F activation.
Sphingosine-1-phosphate (S1P) directly activates CLEC-2F through S1P receptor binding, while convulxin activates it by binding to GPVI. A23187 induces calcium influx, positively affecting CLEC-2F's activity. ADP activates CLEC-2F through P2Y1 and P2Y12 receptor binding. Collagen indirectly enhances CLEC-2F's activity by binding to GPVI. Nobiletin, an indirect activator, upregulates CLEC-2F through the ERK/MAPK pathway. In summary, CLEC-2F emerges as a vital player in natural killer cell modulation, with its activation intricately tied to a diverse array of chemical regulators. These activators modulate multiple pathways, including S1P signaling, protease-activated receptor signaling, PKC-dependent pathways, calcium signaling, and ERK/MAPK pathways, collectively influencing the natural killer cell lectin-like receptor binding activity of CLEC-2F. The nuanced interplay between these regulators sheds light on the complex regulatory mechanisms governing CLEC-2F activation and its potential role in immune response modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
Direct activator of CLEC-2F by binding to S1P receptors. Fingolimod modulates the S1P signaling pathway, positively influencing CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2F function by activating the S1P receptor-dependent pathway. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Activates CLEC-2F through protease-activated receptor (PAR) signaling. Thrombin induces PAR signaling, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2F activation by modulating the PAR-dependent pathway. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Direct activator of CLEC-2F by inhibiting PKC. Bisindolylmaleimide I inhibits PKC, enhancing CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2F function by modulating PKC-dependent pathways and influencing cellular processes associated with CLEC-2F. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Activates CLEC-2F through protein phosphatase inhibition. Calyculin A inhibits protein phosphatases, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2F activation by modulating protein phosphatase-dependent pathways. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
Direct activator of CLEC-2F through TP receptor activation. U46619 activates TP receptors, positively influencing CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2F function by modulating TP receptor-dependent pathways and influencing cellular processes associated with CLEC-2F. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Direct activator of CLEC-2F by activating PKC. PMA activates PKC, enhancing CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2F function by modulating PKC-dependent pathways and influencing cellular processes associated with CLEC-2F. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Direct activator of CLEC-2F through S1P receptor binding. S1P binds to its receptor, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2F activation by modulating the S1P receptor-dependent pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Direct activator of CLEC-2F through calcium signaling. A23187 induces calcium influx, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly promotes CLEC-2F function by modulating calcium-dependent pathways and influencing cellular processes associated with CLEC-2F. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $77.00 $180.00 $312.00 $924.00 $4596.00 $9186.00 | 1 | |
Activates CLEC-2F through P2Y1 and P2Y12 receptor binding. ADP binds to P2Y1 and P2Y12 receptors, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound directly triggers CLEC-2F activation by modulating P2Y1 and P2Y12 receptor-dependent pathways. | ||||||
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Upregulates CLEC-2F through ERK/MAPK pathway activation. Nobiletin activates the ERK/MAPK pathway, positively affecting CLEC-2F's natural killer cell lectin-like receptor binding activity. This compound indirectly activates CLEC-2F by modulating the ERK/MAPK pathway and influencing cellular processes associated with CLEC-2F. | ||||||