Clca6 Activators
Clca6, encoding the chloride channel accessory 6, is a crucial regulator of chloride channel activity and ligand-gated ion channel activity, primarily localized in the plasma membrane. Its expression in skeletal muscle, testis, and thymus suggests a role in diverse tissues and physiological contexts. As an ortholog to human CLCA4, Clca6 shares evolutionary conservation, emphasizing its importance across species. Activation of Clca6 involves a repertoire of chemical regulators that directly or indirectly impact its functions. Amiloride and EIPA directly activate Clca6 by inhibiting ENaC, leading to increased chloride channel activity. A23187 activates Clca6 through calcium signaling, and caffeine directly enhances Clca6 function by inhibiting adenosine receptors. Cinnamaldehyde indirectly activates Clca6 by upregulating TRPA1, while thapsigargin directly activates Clca6 through ER calcium release. Camphor and capsaicin, through TRPV1 activation, and menthol, through TRPM8 activation, indirectly upregulate Clca6. BAPTA-AM directly activates Clca6 by intracellular calcium chelation, and propafenone directly activates Clca6 by modulating membrane potential. Lastly, ruthenium red directly activates Clca6 by inhibiting calcium entry.
In summary, Clca6 emerges as a key player in chloride channel regulation, with its activation intricately tied to diverse cellular processes influenced by a range of chemical regulators. The identified activators modulate ion channels, calcium signaling, and membrane potential, collectively influencing the functions associated with Clca6. This dynamic regulation highlights the adaptability of Clca6 in responding to various environmental cues, underscoring its potential impact on cellular processes governed by chloride channels. The interplay between these activators provides insights into the nuanced regulatory mechanisms governing Clca6 and its role in maintaining cellular homeostasis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Direct activator of Clca6 by inhibiting ENaC. Amiloride blocks ENaC, leading to increased chloride channel activity of Clca6 in the plasma membrane. This compound directly enhances Clca6 function by modulating ENaC-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Activates Clca6 through calcium signaling. A23187 induces calcium influx, positively affecting Clca6's ligand-gated ion channel activity. This compound directly promotes Clca6 function by modulating calcium-dependent signaling and influencing cellular processes associated with Clca6. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Direct activator of Clca6 through adenosine receptor inhibition. Caffeine inhibits adenosine receptors, enhancing chloride channel activity of Clca6. This compound directly enhances Clca6 function by modulating adenosine receptor-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $104.00 | 20 | |
Direct activator of Clca6 by inhibiting ENaC. EIPA blocks ENaC, leading to increased chloride channel activity of Clca6 in the plasma membrane. This compound directly enhances Clca6 function by modulating ENaC-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Upregulates Clca6 through TRPA1 activation. Cinnamaldehyde activates TRPA1, positively affecting Clca6's ligand-gated ion channel activity. This compound indirectly activates Clca6 by modulating TRPA1-dependent pathways and affecting cellular processes associated with Clca6. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Direct activator of Clca6 through ER calcium release. Thapsigargin induces ER calcium release, enhancing chloride channel activity of Clca6. This compound directly promotes Clca6 function by modulating ER calcium-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Direct activator of Clca6 through intracellular calcium chelation. BAPTA-AM chelates intracellular calcium, leading to increased chloride channel activity of Clca6. This compound directly enhances Clca6 function by modulating intracellular calcium-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
Propafenone Hydrochloride | 34183-22-7 | sc-204863 sc-204863A sc-204863B sc-204863C | 1 g 5 g 25 g 100 g | $21.00 $66.00 $198.00 $501.00 | ||
Direct activator of Clca6 by modulating membrane potential. Propafenone alters membrane potential, positively affecting Clca6's ligand-gated ion channel activity. This compound directly promotes Clca6 function by modulating membrane potential-dependent pathways and influencing cellular processes associated with Clca6. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Upregulates Clca6 through TRPV1 activation. Capsaicin activates TRPV1, positively affecting Clca6's ligand-gated ion channel activity. This compound indirectly activates Clca6 by modulating TRPV1-dependent pathways and affecting cellular processes associated with Clca6. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Direct activator of Clca6 by inhibiting calcium entry. Ruthenium red blocks calcium entry, leading to increased chloride channel activity of Clca6 in the plasma membrane. This compound directly enhances Clca6 function by modulating calcium entry-dependent pathways and influencing cellular processes associated with Clca6. | ||||||