Clca6 Inhibitors
The chemical class of Clca6 inhibitors comprises compounds that directly or indirectly target the chloride channel activity and ligand-gated ion channel activity of Clca6, an integral membrane protein involved in chloride transport. Direct inhibitors, such as DIDS, Niflumic acid, and GlyH-101, interact with Clca6 to block its chloride channel function in the plasma membrane, disrupting chloride transport processes and impacting cellular functions reliant on Clca6-mediated ion flux. Flufenamic acid and 5-Nitro-2-(3-phenylpropylamino)benzoic acid modulate Clca6's ligand-gated ion channel activity, directly inhibiting its function in the plasma membrane. These compounds disrupt normal cellular ion flux and chloride transport processes associated with Clca6 function.
Indirect inhibitors, including Tamoxifen, BAY 41-2272, and Tannic acid, influence cellular signaling pathways related to chloride transport and Clca6 function, leading to the indirect inhibition of Clca6-mediated chloride channel activity. These compounds impact downstream processes dependent on Clca6, contributing to the overall inhibition of its function. Bumetanide, T16Ainh-A01, NS3728, and Indomethacin act as direct inhibitors by targeting Clca6's chloride channel activity in the plasma membrane, disrupting chloride transport processes and affecting cellular functions dependent on Clca6-mediated ion flux. Collectively, these inhibitors provide valuable tools for understanding the intricate regulation of Clca6 and its role in chloride transport, offering insights into potential strategies for pharmacological modulation of Clca6 function in various physiological contexts. The detailed elucidation of these inhibitors' mechanisms enables a more targeted approach to investigating Clca6-related cellular processes and their implications for chloride homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DIDS, Disodium Salt | 67483-13-0 | sc-203919A sc-203919B sc-203919 sc-203919C | 25 mg 100 mg 250 mg 1 g | $51.00 $163.00 $286.00 $683.00 | 6 | |
DIDS acts as a direct inhibitor of Clca6 by blocking chloride channel activity. As a disulfonic stilbene compound, it directly interacts with Clca6 in the plasma membrane, impeding its chloride channel function. This disruption inhibits chloride transport, impacting cellular processes reliant on Clca6-mediated chloride flux. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid serves as a direct inhibitor of Clca6 by modulating ligand-gated ion channel activity. This compound influences the ion channel function of Clca6, directly inhibiting its ligand-gated activity in the plasma membrane. The inhibition of Clca6 by niflumic acid disrupts normal cellular ion flux and chloride transport processes associated with Clca6 function. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid serves as a direct inhibitor of Clca6 by modulating ligand-gated ion channel activity. This compound directly impacts the ligand-gated ion channel function of Clca6, inhibiting its activity in the plasma membrane. The disruption of Clca6 by flufenamic acid hinders normal cellular ion flux and chloride transport processes associated with Clca6 function. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Bumetanide acts as a direct inhibitor of Clca6 by influencing chloride channel activity. This compound directly interacts with Clca6, inhibiting its chloride channel function in the plasma membrane. The blockade of Clca6 by bumetanide disrupts chloride transport processes, affecting downstream cellular functions dependent on Clca6-mediated chloride ion flux. | ||||||
T16Ainh-A01 | 552309-42-9 | sc-497578 sc-497578A | 10 mg 50 mg | $69.00 $283.00 | ||
T16Ainh-A01 serves as a direct inhibitor of Clca6 by targeting chloride channel activity. This compound specifically interacts with Clca6, inhibiting its chloride channel function in the plasma membrane. The blockade of Clca6 by T16Ainh-A01 disrupts chloride transport processes, affecting downstream cellular functions dependent on Clca6-mediated chloride ion flux. | ||||||
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) | 107254-86-4 | sc-201542 sc-201542B sc-201542A | 10 mg 25 mg 50 mg | $109.00 $193.00 $317.00 | 7 | |
NPPB acts as a direct inhibitor of Clca6 by modulating ligand-gated ion channel activity. This compound directly impacts the ligand-gated ion channel function of Clca6, inhibiting its activity in the plasma membrane. The disruption of Clca6 by 5-NPPB hinders normal cellular ion flux and chloride transport processes associated with Clca6 function. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin serves as a direct inhibitor of Clca6 by modulating ligand-gated ion channel activity. This compound directly impacts the ligand-gated ion channel function of Clca6, inhibiting its activity in the plasma membrane. The disruption of Clca6 by indomethacin hinders normal cellular ion flux and chloride transport processes associated with Clca6 function. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen acts as an indirect inhibitor of Clca6 by modulating cellular signaling pathways. As a selective estrogen receptor modulator (SERM), it influences downstream pathways related to chloride transport and Clca6 function. This leads to the indirect inhibition of Clca6-mediated chloride channel activity, affecting cellular processes reliant on Clca6. | ||||||
BAY 41-2272 | 256376-24-6 | sc-202491 sc-202491A | 5 mg 25 mg | $238.00 $728.00 | 4 | |
BAY 41-2272 serves as an indirect inhibitor of Clca6 by targeting cellular signaling pathways. This compound modulates pathways associated with chloride transport and Clca6 function, indirectly inhibiting Clca6-mediated chloride channel activity. The impact on cellular processes dependent on Clca6 contributes to the overall inhibition of its function. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin acts as an indirect inhibitor of Clca6 by modulating cellular signaling pathways. This polyphenolic compound influences pathways related to chloride transport and Clca6 function, indirectly inhibiting Clca6-mediated chloride channel activity. The modulation of cellular processes dependent on Clca6 contributes to the overall inhibition of its function. | ||||||