CLC-3 Inhibitors
CLC-3 inhibitors belong to a specific chemical class of compounds that have been studied and designed to selectively target and inhibit the activity of CLC-3, which is a member of the CLC family of chloride channels. CLC-3 plays a role in regulating ion transport across cellular membranes, contributing to cellular excitability and homeostasis. Inhibition of CLC-3 aims to disrupt its ion channel function and potentially modulate chloride ion fluxes in cells. The chemical structures of CLC-3 inhibitors can vary, including synthetic small-molecule compounds and natural products that specifically interact with CLC-3 and interfere with its gating or ion conductance properties.
Researchers have explored various strategies to target CLC-3 and attenuate its effects on ion transport in different cellular contexts. The study of CLC-3 inhibitors provides valuable insights into the complex regulatory mechanisms governing ion channels and cellular physiology. Continued research in this chemical class holds promise for advancing our understanding of CLC-3's role in cellular excitability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
A nonsteroidal anti-inflammatory drug that also acts as a modulator of several chloride channels, possibly inhibiting CLC-3 activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
An antipsychotic agent in research that has been shown to inhibit various ion channels, potentially affecting CLC-3 activity. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
A loop diuretic known to inhibit NKCC (sodium-potassium-chloride cotransporter), which could indirectly influence CLC-3 activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
A calcium channel blocker that might indirectly influence CLC-3 activity through alterations in cellular ion homeostasis. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
An antibiotic that affects various ion channels, potentially including inhibitory effects on CLC-3. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
A heavy metal compound known to affect various ion channels, possibly inhibiting CLC-3. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Similar to Furosemide, as a loop diuretic, it inhibits NKCC and could indirectly impact CLC-3 activity. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $106.00 $208.00 | 6 | |
Another NSAID with known effects on chloride channels, potentially inhibiting CLC-3. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
A diuretic that inhibits NKCC, could indirectly reduce CLC-3 activity through ionic balance disruption. | ||||||