Cid Activators
Cid, short for Centromere Identifier is a protein specifically studied in Drosophila melanogaster (fruit fly). It is a centromeric protein, part of the CENP-A family of proteins, which are crucial for the formation and function of centromeres. Centromeres are key regions on chromosomes where the kinetochore forms and where spindle fibers attach during cell division, ensuring accurate chromosome segregation.
Cid is a histone H3 variant; it replaces the standard histone H3 in the nucleosomes of centromeric chromatin. This replacement is essential for creating a distinct structural and functional domain at the centromere, differentiating it from the rest of the chromosome. Cid-containing nucleosomes confer a unique identity to the centromere, enabling the assembly of the kinetochore, a complex multiprotein structure that mediates chromosome-microtubule interactions during mitosis and meiosis.The presence and proper functioning of Cid are crucial for the integrity of the centromere. Without Cid, centromeres cannot form correctly, leading to errors in chromosome alignment and segregation.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces replication stress, potentially enhancing Cid expression as part of the cell cycle checkpoint response. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, possibly upregulating Cid in response to spindle assembly checkpoint activation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and might influence Cid expression related to kinetochore function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, by disrupting microtubules, could enhance Cid expression as part of a cellular response to impaired spindle function. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA damage, potentially triggering Cid expression in response to genomic instability. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA breaks and could upregulate Cid as part of the cellular DNA damage response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA crosslinks, potentially enhancing Cid expression in response to impaired DNA replication. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA crosslinking, potentially enhancing Cid expression in response to replication stress. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, by causing DNA damage, may trigger Cid expression in the DNA damage checkpoint pathway. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, possibly inducing Cid expression due to replication stress and DNA damage. | ||||||