Cisplatin CAS: 15663-27-1
MF: Cl2H6N2Pt
Cisplatin is an apoptosis inducer and caspase-3 activator.

Cisplatin (CAS 15663-27-1)

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同义词: CDDP; cis-Diammineplatinum(II) dichloride
应用; Cisplatin is an apoptosis inducer and caspase-3 activator
CAS号码: 15663-27-1
纯度: ≥99%
分子量: 300.05
分子式: Cl2H6N2Pt
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


参考文献

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438
2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072
3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837
4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

外观 :
Powder or crystalline
物理状态 :
Solid
溶解度 :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
保存 :
Store at room temperature
熔点 :
270° C
密度 :
3.74 g/cm3
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
TP2450000
PubChem CID :
441203
默克索引 :
14: 2317
MDL 号码 :
MFCD00011623
EC号码 :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

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PMID: # 29267289  Chen, Y. et al. 2017. PLoS ONE. 12: e0187222.

PMID: # 29132253  İnci, D. et al. 2017. J. Biomol. Struct. Dyn. 1-24.

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PMID: # 28339648  Pendergraft, SS. et al. 2017. Biol. Reprod. 96: 720-732.

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