CIB2 Inhibitors
Chemical inhibitors of CIB2 target various aspects of calcium signaling pathways, which are crucial for the protein's function. W-7 Hydrochloride, Trifluoperazine, and Calmidazolium chloride are exemplary chemicals that inhibit calmodulin, a protein that interacts with CIB2 through calcium-mediated processes. By antagonizing calmodulin, these inhibitors prevent the normal calcium-dependent regulatory activities of CIB2. Since CIB2 activity is modulated by calcium, the use of L-type calcium channel blockers such as Nifedipine, Verapamil, Diltiazem, and Bepridil can indirectly inhibit CIB2 by reducing calcium influx, thus decreasing the calcium available for CIB2 to bind. This decrease in intracellular calcium levels directly leads to a reduced function of CIB2, which relies on calcium binding for its activation and subsequent signaling.
Furthermore, inhibitors like KN-93 Phosphate disrupt downstream effects of calcium signaling by inhibiting calcium/calmodulin-dependent protein kinase II (CaMKII), which can result in the functional inhibition of CIB2 activity within these pathways. ML-9, while primarily an inhibitor of myosin light-chain kinase, also affects kinases within calcium signaling pathways that CIB2 is involved in, thereby altering CIB2 function. Phenothiazine disrupts calcium signaling by affecting calmodulin activity, which can prevent its association with CIB2, leading to an inhibition of the protein's functions that are mediated by calcium. Mibefradil, a T-type calcium channel blocker, like the L-type blockers, reduces intracellular calcium concentrations, thus inhibiting CIB2 function. Lastly, Ruthenium Red, by inhibiting calcium uptake and binding to calcium-binding proteins, can bind to and inhibit CIB2 by blocking its calcium-binding sites, thereby inhibiting its activity.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 Hydrochloride is a calmodulin antagonist that can inhibit calcium/calmodulin-dependent processes. CIB2 binds calcium and interacts with calmodulin; thus, by inhibiting calmodulin, W-7 Hydrochloride can impair the calcium-dependent functions of CIB2, leading to functional inhibition. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 Phosphate is an inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Given that CIB2 has a role in calcium signaling pathways, inhibition of CaMKII can disrupt downstream effects of calcium signaling, possibly leading to the functional inhibition of CIB2 activity in these pathways. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Calmidazolium chloride is another calmodulin inhibitor that competes with calcium ions and can block the binding of calmodulin to CIB2. By inhibiting calmodulin, it indirectly inhibits CIB2's calcium-dependent conformation and function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is an L-type calcium channel blocker. By reducing calcium influx, it can indirectly inhibit the calcium-binding ability of CIB2, leading to functional inhibition given that CIB2's activity is calcium-dependent. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is another L-type calcium channel blocker which can decrease intracellular calcium levels. This may lead to a reduction in CIB2 activity since CIB2 requires calcium binding for its function. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem functions similarly to verapamil and nifedipine as a calcium channel blocker, leading to decreased calcium availability for proteins like CIB2 that depend on calcium for their activity. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9 is an inhibitor of myosin light-chain kinase (MLCK) and can also affect other kinases involved in calcium signaling. As CIB2 interacts with calcium-binding proteins and is involved in signal transduction, ML-9 can indirectly inhibit CIB2 by altering calcium signaling. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker with a broad range of activity, including the inhibition of calmodulin binding. The inhibition of calcium signaling pathways can indirectly inhibit the functionality of CIB2 since its activity is modulated by calcium. | ||||||
Phenothiazine | 92-84-2 | sc-250686 sc-250686A | 50 g 250 g | $23.00 $43.00 | ||
Phenothiazine is a compound that can disrupt calcium signaling by affecting calmodulin activity. The inhibition of calmodulin can prevent its association with CIB2, indirectly inhibiting CIB2's calcium-mediated functions. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil is a T-type calcium channel blocker that can decrease intracellular calcium levels. This reduction can impede the calcium-dependent function of CIB2, leading to its functional inhibition. | ||||||