CHMP4A Activators
CHMP4A activators are a diverse set of chemical compounds that facilitate the protein's role in endosomal sorting, membrane remodeling, and mitophagy. These activators work by altering cellular membranes or signaling pathways to indirectly enhance CHMP4A's functions. Phosphatidic Acid and Lysobisphosphatidic Acid specifically impact the lipid composition and curvature of endosomal membranes, promoting the recruitment and activity of CHMP4A, which is critical for vesicle formation and release. PIKfyve inhibitors like YM201636 elevate PI(3)P levels, which bolster CHMP4A's assembly at the membrane. Zinc Chloride and Cardiolipin directly engage with membrane-associated processes, stabilizing CHMP4A's interaction with the lipid bilayer and facilitating its role in mitophagy-related membrane remodeling. Nicotinamide Mononucleotide, through its role in NAD+ metabolism, can affect membrane dynamics, indirectly bolstering the function of CHMP4A.
The activity of CHMP4A is further influenced by changes in intracellular conditions and membrane trafficking demands. Urolithin A, by promoting mitophagy, and mdivi-1, by disrupting mitochondrial fission, create a cellular environment that necessitates enhanced CHMP4A function for mitochondrial quality control. Changes in ion concentrations, such as those caused by Calcium Chloride, can also augment endosomal trafficking, implicating CHMP4A's activity in these processes. Moreover, compounds like EIPA and Dynasore, by hindering alternative endocytic mechanisms, potentially increase reliance on CHMP4A-mediated pathways. Neomycin Sulfate disrupts phospholipid interactions, which may lead to compensatory upregulation of CHMP4A's membrane remodeling activities. Collectively, these activators, through their targeted effects on cellular pathways and membrane composition, ensure the amplified functionality of CHMP4A without directly increasing its expression levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysobisphosphatidic acid modulates endosomal membrane composition and curvature, which can enhance the recruitment and polymerization activity of CHMP4A on endosomal membranes. | ||||||
YM201636 | 371942-69-7 | sc-204193 | 5 mg | $213.00 | 6 | |
By inhibiting PIKfyve, this compound increases the levels of PI(3)P on endosomal membranes, indirectly enhancing the membrane recruitment and activity of the CHMP4A protein. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can stabilize membrane association of ESCRT-III proteins; thus, zinc chloride can enhance the membrane association and activity of CHMP4A in vesicle formation and release. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
β-Nicotinamide mononucleotide (NMN), a precursor of NAD+, has been shown to influence membrane dynamics, which could indirectly enhance the membrane remodeling functions of CHMP4A. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $200.00 $450.00 $700.00 $1200.00 | 10 | |
Urolithin A induces mitophagy, a process that relies on CHMP4A-mediated membrane remodeling, thus potentially enhancing CHMP4A activity indirectly through increased functional demand. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $66.00 $124.00 $246.00 $456.00 | 13 | |
Mdivi-1 disrupts mitochondrial fission, which could indirectly increase the demand for CHMP4A's function in alternative mitochondrial quality control pathways like mitophagy. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Elevated intracellular calcium levels can enhance membrane trafficking processes, potentially increasing the activity of CHMP4A in endosomal sorting and vesicle release. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $102.00 | 20 | |
EIPA inhibits macropinocytosis and can enhance the demand for CHMP4A in compensatory endosomal sorting and trafficking processes. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin-dependent endocytosis, potentially increasing the role of CHMP4A in alternative endosomal sorting and trafficking routes. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $26.00 $34.00 | 20 | |
Neomycin sulfate disrupts phospholipid interactions on cellular membranes, which can indirectly enhance the membrane remodeling activities of CHMP4A. | ||||||