Molecular structure of YM201636, CAS Number: 371942-69-7
YM201636 (CAS 371942-69-7)
See product citations (6)
Alternate Names:
YM201636 is known as a PIKfyve Inhibitor.
Application:
YM201636 is a selective, potent inhibitor of phosphatidylinositol phosphate kinase PIKfyve that can completely block PI 3-kinase activation.
CAS Number:
371942-69-7
Purity:
≥98%
Molecular Weight:
467.49
Molecular Formula:
C25H21N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
YM201636 is a potent inhibitor of phosphatidylinositol phosphate kinase PIKfyve, which has been noted to synthesize phosphatidylinositol 3,5-bisphosphate and is also reported to be involved in sorting endosomal transport. YM201636 displays the ability to inhibit basal and insulin-activated 2-deoxyglucose uptake, as well as completely block insulin-dependent activation of class IA PI 3-kinase. The selectivity of YM201636 is shown to be less potent to p110α and insensitive to Fabl (yeast orthologue). In serum-starved NIH3T3 cells, YM201636 significantly decreased production of PtdIns(3,5)P2 by 80%.
YM201636 (CAS 371942-69-7) References
- A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. | Jefferies, HB., et al. 2008. EMBO Rep. 9: 164-70. PMID: 18188180
- YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. | Ikonomov, OC., et al. 2009. Biochem Biophys Res Commun. 382: 566-70. PMID: 19289105
- Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. | Kerr, MC., et al. 2010. EMBO J. 29: 1331-47. PMID: 20300065
- Phosphoinositides direct equine infectious anemia virus gag trafficking and release. | Fernandes, F., et al. 2011. Traffic. 12: 438-51. PMID: 21176037
- The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness. | Dupuis-Coronas, S., et al. 2011. J Biol Chem. 286: 32105-14. PMID: 21737449
- The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. | Dukes, JD., et al. 2012. PLoS One. 7: e28659. PMID: 22396724
- Identification of a novel signaling pathway and its relevance for GluA1 recycling. | Seebohm, G., et al. 2012. PLoS One. 7: e33889. PMID: 22470488
- Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. | Sbrissa, D., et al. 2012. Am J Physiol Cell Physiol. 303: C436-46. PMID: 22621786
- WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation. | Mauthe, M., et al. 2012. Int J Cell Biol. 2012: 179207. PMID: 22829830
- PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses. | Hazeki, K., et al. 2013. PLoS One. 8: e73894. PMID: 24040108
- Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy. | Hou, JZ., et al. 2019. Oncol Rep. 41: 1971-1979. PMID: 30569119
- The effects of PIKfyve inhibitor YM201636 on claudins and malignancy potential of nonsmall cell cancer cells. | DoĞan, E., et al. 2021. Turk J Biol. 45: 26-34. PMID: 33597819
- Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance. | Du, C., et al. 2022. Commun Biol. 5: 738. PMID: 35871252
- Bioinformatics and network-based screening and discovery of potential molecular targets and small molecular drugs for breast cancer. | Alam, MS., et al. 2022. Front Pharmacol. 13: 942126. PMID: 36204232
Inhibitor of:
ACAP2, AP-4β, AP-4σ, ATP6V0E1, C20orf29, CHMP2B, CHMP4B, DENND6B, FMVB12B, golgin 245, INPP5J, IST1, MON1B, MTMR15, Munc13-3, MVB12B, Nir2, PI 3-kinase C2α, PI 3-kinase C2β, PIP2, PIP5KIII, PIPK I γ, Rab 9A, Rabex-5, Reticulon, RGS1, RUFY1, Sec23IP, Sec24B, Slac2-c, SMAP1, TBC1D19, TBC1D22B, Unc18-2, Vacuolar Protein Sorting (VPS), VPS35, VPS8, WDR7, and ZFYVE28.Activator of:
CHMP4A, GRASP, MON2, mucolipin 1, MVB12A, MVB12B, NEURL4, SNX26, TBC1D22A, Unc18-2, V-ATPase C1, VAC14, and VPS26B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM201636, 5 mg | sc-204193 | 5 mg | $217.00 |