Chibby Activators
Activators of the protein Chibby, which is involved in the Wnt signaling pathway, represent a specialized class of chemical compounds that function to increase the activity of this protein within the cell. The Wnt signaling pathway is a complex network of proteins that plays a crucial role in regulating gene expression, cell behavior, and development. Chibby acts as a negative regulator of beta-catenin, a central component of the Wnt pathway, by competing with TCF/LEF family members for beta-catenin binding, thereby influencing the transcriptional activity of Wnt target genes.
Chibby activators might directly enhance the protein's ability to bind to beta-catenin or promote its stability within the cell. Direct activators could bind to Chibby and induce a conformational change that favors its interaction with beta-catenin, or they might prevent its degradation, thus increasing the cellular levels of functional Chibby protein. This would, in turn, result in a more pronounced inhibition of beta-catenin's activity in the absence of Wnt signaling, leading to a decrease in the expression of Wnt target genes. Alternatively, indirect activators of Chibby would not bind to the protein itself but would instead modulate cellular processes that result in increased Chibby activity. These could include small molecules that upregulate the expression of the Chibby gene, enhancing the production of the protein within the cell. They might also influence post-translational modifications of Chibby, such as phosphorylation or ubiquitination, which can affect the protein's stability, localization, or affinity for beta-catenin.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin enhances the activity of adenylate cyclase, which increases cyclic AMP (cAMP) levels. Higher cAMP levels activate protein kinase A (PKA), which can subsequently phosphorylate β-catenin, a protein that Chibby directly interacts with to inhibit Wnt/β-catenin signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase that phosphorylates β-catenin leading to its degradation. Inhibition of GSK-3β stabilizes β-catenin, enhancing the pool of β-catenin that Chibby can interact with, thereby enhancing its functional activity. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
Biochanin A inhibits the kinase activity of GSK-3β, leading to the stabilization of β-catenin. This increases the pool of β-catenin that Chibby can interact with, thereby enhancing its functional activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a potent inhibitor of GSK-3β. Its inhibition stabilizes β-catenin, enlarging the pool of β-catenin that Chibby can interact with. This enhances Chibby's function in inhibiting Wnt/β-catenin signaling. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine activates the Smoothened (SMO) receptor, a component of the Sonic Hedgehog (SHH) pathway. Activation of SMO leads to the activation of β-catenin, providing more substrates for Chibby to interact with and enhancing its functional activity. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $210.00 $520.00 | 31 | |
SAG is a Smoothened agonist that activates the SMO receptor, leading to the activation of β-catenin. This increases the pool of β-catenin that Chibby can interact with, thereby enhancing its functional activity. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine is a Smoothened antagonist that indirectly activates β-catenin by inhibiting the negative regulator SMO. This increases the pool of β-catenin that Chibby can interact with, thereby enhancing its function in inhibiting Wnt/β-catenin signaling. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is a Smoothened antagonist that indirectly activates β-catenin by inhibiting the negative regulator SMO. This increases the pool of β-catenin that Chibby can interact with, thereby enhancing its function in inhibiting Wnt/β-catenin signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that indirectly affects β-catenin by inhibiting ERK signaling, which can phosphorylate and stabilize β-catenin. This increases the pool of β-catenin that Chibby can interact with, thereby enhancing its functional activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 is a potent GSK-3β inhibitor that stabilizes β-catenin, increasing the pool of β-catenin that Chibby can interact with, thereby enhancing its functional activity. | ||||||