Biochanin A CAS: 491-80-5
MF: C16H12O5
MW: 284.27
A nitric oxide synthase inhibitor and apoptosis inducer.

Biochanin A (CAS 491-80-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 121ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Biochanin A is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Nomi alternativi: 5,7-Dihydroxy-4'-methoxyisoflavone; 4'-Methylgenistein
Applicazione: Biochanin A is a nitric oxide synthase inhibitor and apoptosis inducer
Numero CAS: 491-80-5
Purezza: ≥98%
Peso molecolare: 284.27
Formula molecolare: C16H12O5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Biochanin A, an isoflavone, is a natural plant phytoestrogen which has been reported to be an antiproliferative and anti-inflammatory agent. Studies show that this compound inhibits iNOS expression and lipopolysacharide (LPS)-induced nitric oxide production in macrophages. Additionally, Biochanin A displays the ability to block phosphorylation of IκBα and p38 MAPK, which prevents NF-κB activation. Furthermore, Biochanin A has been observed to suppress IL-6, IL-1β, and TNF-α production.


Referenze

1. Chae, Y.H. et al. 1992. Chem. Biol. Interact. 82(2): 181-193. PMID: 1568269

2. Jing, Y. and Waxman, S. 1995. Anticancer Res. 15(4): 1147-1152. PMID: 7653993

3. Rooke, N. et al. 2000. J. Med. Chem. 43(22): 4169-4179. PMID: 11063613

4. Khan, I.A. et al. 2000. J. Nat. Prod. 63(10): 1414-1416. PMID: 11076565

5. Tasdemir, D. et al. 2006. J. Med. Chem. 49(11): 3345-3353. PMID: 16722653

6. Salem, M.M. and Werbovetz, K.A. 2006. J. Nat. Prod. 69(1): 43-49. PMID: 16441066

7. Schuster, D. et al. 2008. J. Med. Chem. 51(14): 4188-4199. PMID: 18533708

8. Thors, L. et al. 2010. Br. J. Pharmacol. 160(3): 549-560. PMID: 20590565

9. Kole, L. et al. 2011. Eur. J. Pharmacol. 653(1-3): 8-15. PMID: 21147093

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in water (<1 mg/ml at 25° C), chloroform, methanol, DMSO (57 mg/ml at 25° C), and ethanol (9 mg/ml at 25° C).
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
210-213° C
Punto di ebollizione :
518.6° C at 760 mmHg (Predicted)
Densità :
1.4 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.67 (Predicted)
IC50 :
MAO: IC50 = 0.4 µM (human); Fatty acid synthase: IC50 = 8 µM (plasmodium falciparum); 17β-HSD2: IC50 = 9.9 µM (human); Trypanosoma brucei brucei: IC50 = 12.3 µM; Giardia intestinalis: IC50 = 3.5 µg/ml
Ki Data :
Carbonyl reductase 1: Ki= 2.03 µM (human); CYP19: Ki= 12 µM (human)
Valori pK :
pKa: 6.5 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
DJ3002500
PubChem CID :
Indice Merck :
14: 10423
Numero MDL :
MFCD00006839
Numero EC :
207-744-7
Registro Beilstein :
278107
SMILES :
COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 117ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.