CHERP Inhibitors
Chemical inhibitors of CHERP can exert their inhibitory effects through various mechanisms, primarily by disrupting the signaling pathways that CHERP is known to participate in. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit the phosphorylation events that are crucial for the function of CHERP within calcium-mediated signal transduction pathways. By impeding these phosphorylation events, Staurosporine can impede the functional activity of CHERP. Similarly, Thapsigargin and Cyclopiazonic Acid, both inhibitors of the SERCA pump, lead to elevated cytosolic calcium levels, which disrupt the normal calcium-dependent signaling processes involving CHERP. Tetracaine, by affecting sodium channel function and thereby the membrane potential, can alter calcium signaling pathways in which CHERP functions, leading to its inhibition.
Moreover, Ruthenium Red and Xestospongin C, inhibitors of calcium channels and IP3 receptors respectively, can prevent calcium influx and release within the cell, thus impeding the calcium-dependent regulatory functions of CHERP. 2-APB, another IP3 receptor inhibitor, also impacts the calcium release from endoplasmic reticulum, which is critical for CHERP's activity in these pathways. The W-7 and Calmidazolium Chloride, as calmodulin antagonists, inhibit calcium/calmodulin-dependent protein kinases and the interaction of calmodulin with other proteins, which could potentially inhibit the activities of CHERP. KN-93 specifically targets CaMKII, a kinase critical in calcium signaling pathways, and its inhibition can disrupt downstream effects that modulate CHERP's functional role. ML-9's inhibition of MLCK, a kinase involved in calcium/calmodulin-dependent processes, can indirectly affect CHERP's role in those pathways. Lastly, SKF-96365 impedes receptor-mediated calcium entry and store-operated channels, which are significant for the regulation of calcium signaling-a pathway essential for the functional activity of CHERP.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. CHERP has been shown to be involved in calcium-mediated signal transduction. Staurosporine's kinase inhibition can impair phosphorylation events essential for CHERP's function within these signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels. Given that CHERP is involved in calcium signaling, the dysregulation of calcium homeostasis by thapsigargin can disrupt CHERP's normal function in calcium-dependent signaling processes. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a local anesthetic that blocks voltage-gated sodium channels. By altering sodium channel function, tetracaine can affect the membrane potential and thereby influence calcium signaling pathways in which CHERP is involved, leading to its functional inhibition. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is an inhibitor of calcium channels, including ryanodine receptors. By blocking calcium influx, it can prevent the calcium-dependent regulation of CHERP within cellular signaling pathways. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is a modulator that can inhibit IP3 receptors. Since CHERP is implicated in signaling pathways involving IP3 receptors, 2-APB can inhibit the calcium release from the ER, thus interfering with CHERP's activity in these pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin antagonist that can inhibit calcium/calmodulin-dependent protein kinases. As CHERP is associated with calcium signaling, the inhibition of calmodulin function by W-7 can impede CHERP's activity in calcium-mediated signaling pathways. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Since CHERP is involved in calcium signaling pathways, KN-93's inhibition of CaMKII can disrupt downstream effects on CHERP's functional role. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the SERCA pump, similar to thapsigargin, and disrupts calcium homeostasis. This disruption can interfere with the pathways of calcium signaling where CHERP is a functional component. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9 is an inhibitor of myosin light-chain kinase (MLCK). Since MLCK is involved in calcium/calmodulin-dependent processes, ML-9's inhibition of MLCK can indirectly affect CHERP's role in these signaling pathways. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C is an inhibitor of the IP3 receptor. By blocking the action of IP3 receptors, it can inhibit calcium release from the endoplasmic reticulum, potentially disrupting the calcium-dependent functions of CHERP. | ||||||