Che-1 Activators
Che-1 activators are molecules that modulate the function of Che-1, a protein involved in regulating gene transcription, cell cycle progression, and response to DNA damage. Che-1, also known as AATF or apoptosis-antagonizing transcription factor, interacts with several key proteins within the cell nucleus to execute its functions, including transcription factors and components of the transcriptional machinery. It has been implicated in the regulation of genes that control cell cycle checkpoints and apoptosis.
The activation of Che-1 can be achieved through multiple mechanisms, with direct activators typically binding to the protein to enhance its stability, promote its interaction with transcriptional partners, or increase its affinity for DNA. This could involve allosteric modulators that bind to Che-1 at a site distinct from the active site, inducing a conformational change that results in an increased ability to bind DNA or interact with other proteins involved in transcription regulation. Indirect activators might act on pathways that modulate the post-translational modifications of Che-1, such as phosphorylation, acetylation, or ubiquitination. For example, compounds that inhibit the activity of kinases known to phosphorylate Che-1 may result in an increase in its activity by preventing the addition of phosphate groups that could negatively regulate its function. Similarly, inhibitors of deacetylases could lead to increased acetylation of Che-1, potentially enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol can activate the estrogen receptor (ER), which has been found to interact with Che-1. Upon activation, ER can recruit Che-1 to estrogen-responsive genes, promoting their transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and PKA activity. PKA can phosphorylate Che-1, enhancing its stability and transcriptional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/AKT pathway. AKT can phosphorylate and stabilize Che-1, enhancing its function as a transcriptional coactivator. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates the retinoic acid receptor (RAR), which can interact with Che-1. Activation of RAR can recruit Che-1 to retinoic acid-responsive genes, promoting their transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone activates the glucocorticoid receptor (GR). Che-1 has been found to interact with activated GR, and can be recruited to glucocorticoid-responsive genes to enhance their transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting HDACs, it can cause hyperacetylation of histones at Che-1 target genes, potentially enhancing the recruitment and transcriptional activity of Che-1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit the NF-κB signaling pathway. Che-1 is a negative regulator of NF-κB, and inhibition of NF-κB by curcumin can enhance the function of Che-1. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin can cause DNA damage, activating the ATM/ATR pathway. Che-1 is a target of ATR, and its phosphorylation by ATR upon DNA damage can enhance its activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor. By inhibiting HDACs, it can cause hyperacetylation of histones at Che-1 target genes, potentially enhancing the recruitment and transcriptional activity of Che-1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can enhance the activity of ULK1. ULK1 can phosphorylate Che-1, promoting Che-1-induced autophagy. | ||||||