Date published: 2025-10-20

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Che-1 Activators

Che-1 activators are molecules that modulate the function of Che-1, a protein involved in regulating gene transcription, cell cycle progression, and response to DNA damage. Che-1, also known as AATF or apoptosis-antagonizing transcription factor, interacts with several key proteins within the cell nucleus to execute its functions, including transcription factors and components of the transcriptional machinery. It has been implicated in the regulation of genes that control cell cycle checkpoints and apoptosis.

The activation of Che-1 can be achieved through multiple mechanisms, with direct activators typically binding to the protein to enhance its stability, promote its interaction with transcriptional partners, or increase its affinity for DNA. This could involve allosteric modulators that bind to Che-1 at a site distinct from the active site, inducing a conformational change that results in an increased ability to bind DNA or interact with other proteins involved in transcription regulation. Indirect activators might act on pathways that modulate the post-translational modifications of Che-1, such as phosphorylation, acetylation, or ubiquitination. For example, compounds that inhibit the activity of kinases known to phosphorylate Che-1 may result in an increase in its activity by preventing the addition of phosphate groups that could negatively regulate its function. Similarly, inhibitors of deacetylases could lead to increased acetylation of Che-1, potentially enhancing its activity.

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Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

H2O2 can cause oxidative stress, leading to the activation of the ATM/ATR pathway. Che-1 is a target of ATR, and its phosphorylation by ATR under oxidative stress conditions can enhance its activity.