CHCHD8 Activators

CHCHD8 include various compounds that engage with mitochondrial function and biogenesis. Coenzyme Q10 is integral to the electron transport chain, enhancing mitochondrial oxidative phosphorylation, which in turn can increase CHCHD8 activity. Similarly, Methylene Blue serves as an alternative electron carrier within the electron transport chain, supporting the stabilization of mitochondrial function and potentially elevating the function of CHCHD8. Nicotinamide adenine dinucleotide (NAD+) contributes to redox reactions and the operation of sirtuins and PARPs that are crucial for mitochondrial upkeep, which can enhance CHCHD8 activity. Moreover, Resveratrol, by activating sirtuins, particularly SIRT1, may improve mitochondrial health and CHCHD8 activity through the regulation of mitochondrial biogenesis.

Spermidine promotes autophagy, a process that can include the renewal of mitochondria, thus supporting mitochondrial turnover and CHCHD8 activity. Pyrroloquinoline quinone (PQQ) is known to encourage the formation of new mitochondria, indirectly supporting CHCHD8 activity. Alpha-lipoic acid and Retinoic acid both play a role in mitochondrial metabolism and gene expression for mitochondrial function, respectively, which can support CHCHD8 activity. Sulforaphane activates the Nrf2 pathway, which helps maintain mitochondrial integrity, thus benefiting CHCHD8 function. Carnitine is essential for fatty acid transport into mitochondria for β-oxidation, which enhances mitochondrial function and subsequently CHCHD8 activity. Tauroursodeoxycholic acid (TUDCA) maintains mitochondrial health, which can indirectly boost the activity of CHCHD8. Lastly, Melatonin regulates mitochondrial biogenesis, dynamics, and overall function, thereby promoting the activity of CHCHD8 within the cellular powerhouse.