CHCHD3 Activators

CHCHD3 activators encompass a diverse group of compounds that indirectly enhance the functional activity of CHCHD3 through various mitochondrial pathways. For instance, polyphenolic compounds such as Resveratrol activate SIRT1, which influences mitochondrial biogenesis by deacetylating PGC-1α, a coactivator that directly impacts mitochondrial quantity and quality. This process would likely bolster the activity of CHCHD3 by ensuring an optimal mitochondrial environment. Similarly, direct PGC-1αactivators like CAY10566 or AMPK activators such as AICAR and Metformin also work indirectly by upregulating mitochondrial biogenesis, which is expected to promote CHCHD3 function due to the protein's localization in the mitochondrial inner membrane. Other compounds, like NAD+ and SRT1720, enhance sirtuin activity, which further supports mitochondrial health, indirectly contributing to the functional enhancement of CHCHD3. Furthermore, agents SS-31 (Elamipretide) modulate mitochondrial dynamics, stabilizing mitochondrial membranes to maintain mitochondrial integrity.

Additionally, compounds like Bezafibrate and Leucine act as indirect activators by stimulating peroxisome proliferator-activated receptors and mTOR signaling, respectively, both leading to increased mitochondrial biogenesis and potentially improving CHCHD3 function. Urolithin A's promotion of mitophagy ensures the removal of dysfunctional mitochondria, leading to a healthier mitochondrial population that could indirectly enhance CHCHD3's role in mitochondrial structure and function. Coenzyme Q10's role in ATP synthesis is crucial for maintaining the mitochondrial energy balance, and its optimization of energy production is another route through which CHCHD3 activity could be indirectly enhanced, as CHCHD3 is vital for maintaining mitochondrial network organization and integrity.