CENP-L Inhibitors
CENP-L inhibitors encompass an array of chemical compounds that suppress the functionality of CENP-L within the cell division process. The mechanism of action for these inhibitors typically involves interference with various stages of the cell cycle or the chromosomal architecture, which is critical for CENP-L's role in chromosome segregation. For instance, PD 0332991 targets CDK4/6 to induce G1 phase arrest, which in turn, precludes the need for CENP-L activity during mitosis. Similarly, Trichostatin A, by inhibiting histone deacetylase, disrupts the chromatin structure, compromising the chromosomal dynamics where CENP-L is instrumental. Other inhibitors such as Aurintricarboxylic acid and Mitomycin C directly target DNA replication and integrity – processes that are foundational for CENP-L function during cell division.
Furthermore, inhibitors like Camptothecin and Amsacrine destabilize DNA topology by targeting topoisomerases, while compounds such as Vinblastine, Nocodazole, and Griseofulvin interfere with microtubule dynamics, which are crucial for CENP-L in ensuring proper chromosome attachment and segregation. Meanwhile, Etoposide induces DNA breaks and arrest in the cell cycle, thus indirectly reducing the functional necessity of CENP-L. ZM-447439's inhibition of Aurora kinases and Taxol's stabilization of microtubules both result in mitotic arrest, further diminishing the functional relevance of CENP-L in its critical role during chromosome segregation. Collectively, these inhibitors, through their precise actions on cell cycle regulation and chromosomal architecture, effectively diminish the role of CENP-L in cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
PD 0332991 is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. CENP-L, being a centromere protein, is implicated in cell division. By inhibiting CDK4/6, PD 0332991 leads to G1 phase arrest, thereby indirectly diminishing CENP-L function, which is essential during the cell cycle's mitosis phase. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It alters chromatin structure and affects gene expression. Since CENP-L is associated with chromosome condensation and segregation, Trichostatin A's action can lead to an improper chromosomal architecture, indirectly diminishing the functional role of CENP-L in the mitotic spindle formation. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic acid is an inhibitor of topoisomerase II. The enzymatic activity of topoisomerase II is crucial for DNA replication and chromosome segregation, where CENP-L plays a role. By inhibiting topoisomerase II, this compound indirectly diminishes the function of CENP-L due to disrupted DNA decatenation during the cell cycle. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is an alkylating agent that creates DNA cross-links. These cross-links prevent DNA replication and transcription, indirectly diminishing the function of CENP-L by preventing proper chromosome condensation and segregation during mitosis. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor. By stabilizing the transient break in the DNA strand made by topoisomerase I, it prevents DNA relegation, leading to DNA damage and cell cycle arrest. This action indirectly diminishes CENP-L's role in mitosis. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is an acridine derivative that intercalates into DNA and inhibits topoisomerase II. By disrupting the normal topology of DNA during the cell cycle, it indirectly diminishes the function of CENP-L, which is important for chromosome dynamics during mitosis. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II. By preventing the religation of DNA strands, etoposide leads to DNA breaks and cell cycle arrest, thereby indirectly diminishing the function of CENP-L during chromosome segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation. Since CENP-L is required for the proper attachment of chromosomes to the mitotic spindle, the disruption of microtubules by vinblastine indirectly diminishes the function of CENP-L. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule polymerization. As microtubules are essential for chromosome segregation to which CENP-L contributes, nocodazole's action indirectly diminishes CENP-L's function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Since Aurora kinases are critical for chromosome alignment and segregation, their inhibition by ZM-447439 indirectly diminishes the function of CENP-L, which is implicated in these processes. | ||||||