Date published: 2025-11-21

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Cdk2 Inhibitors

Cyclin-dependent kinase 2 (Cdk2) inhibitors represent a class of chemical compounds that play a pivotal role in regulating the progression of the cell cycle. Cdk2, a member of the cyclin-dependent kinase family, is a serine/threonine kinase enzyme that partners with various cyclins to control the transition between different phases of the cell cycle. The inhibitors targeting Cdk2 are designed to modulate its activity, primarily by preventing the interaction between Cdk2 and its binding partner, cyclin. By doing so, these inhibitors disrupt the phosphorylation events that are critical for cell cycle progression. Cdk2 inhibitors exhibit a diverse range of chemical structures, each tailored to specifically interact with the active site of the enzyme. These compounds often contain conserved motifs that are crucial for binding to the ATP-binding pocket of Cdk2. By binding to this pocket, the inhibitors compete with ATP molecules, thereby obstructing the enzymatic activity of Cdk2. This binding interaction leads to a halt in the phosphorylation of key substrates involved in cell cycle progression, ultimately resulting in cell cycle arrest. The rational design of Cdk2 inhibitors involves a detailed understanding of the enzyme's structural features and catalytic mechanisms, allowing chemists to fine-tune the compounds for optimal binding affinity and specificity.

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Items 1 to 10 of 53 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$254.00
41
(3)

Flavopiridol (CAS 146426-40-6) is a chemical compound known for its role as a Cdk2 inhibitor, affecting cell cycle progression.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

Roscovitine is a competitive inhibitor of CDK2 by binding to the ATP site and preventing substrate phosphorylation. It induces cell cycle arrest and apoptosis.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine (CAS 62996-74-1) is a compound acting as a Cdk2 inhibitor. It affects cell cycle progression by targeting Cdk2, a key regulator of cell division.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$90.00
$240.00
17
(1)

Ro 31-8220 (CAS 138489-18-6) is a chemical compound recognized for its role as a Cdk2 inhibitor. It hinders the activity of Cdk2, a crucial protein involved in cell cycle regulation. The compound's interaction with Cdk2 underscores its significance in cellular research.

CID 755673

521937-07-5sc-205246
10 mg
$203.00
1
(1)

CID 755673 (CAS 521937-07-5) is a chemical compound that functions as a Cdk2 inhibitor, modulating its activity. It affects cell cycle regulation by targeting Cdk2, a crucial protein involved in cell division control.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$60.00
$150.00
$226.00
$495.00
1
(1)

Kenpaullone is a CDK2/cyclin E inhibitor that suppresses kinase activity, inhibiting substrate phosphorylation and affecting cell cycle progression.

Flavopiridol Hydrochloride

131740-09-5sc-207687
10 mg
$311.00
(2)

Flavopiridol HCL inhibits CDK2 by binding to the ATP pocket, preventing ATP binding and subsequent phosphorylation of target substrates.

Purvalanol A

212844-53-6sc-224244
sc-224244A
1 mg
5 mg
$71.00
$291.00
4
(2)

Purvalanol A (CAS 212844-53-6) is a chemical compound known for its role as a Cdk2 inhibitor. It interacts with the Cdk2 enzyme, modulating its activity and affecting cellular processes.

Cdk2 Inhibitor II

222035-13-4sc-221409A
sc-221409
sc-221409B
sc-221409C
sc-221409D
sc-221409E
sc-221409F
500 µg
1 mg
5 mg
50 mg
500 mg
1 g
5 g
$54.00
$87.00
$275.00
$1224.00
$6125.00
$9180.00
$26520.00
19
(4)

Cdk2 Inhibitor II, with CAS number 222035-13-4, is a compound designed to inhibit Cdk2, a key protein involved in cell cycle regulation. By targeting Cdk2, this chemical hinders specific cellular processes, offering potential insights into cellular function modulation.

SU 9516

377090-84-1sc-222330
sc-222330A
5 mg
25 mg
$122.00
$383.00
3
(1)

SU 9516 (CAS 377090-84-1) is a chemical compound known for its role as a Cdk2 inhibitor. It affects the activity of Cdk2, a crucial enzyme involved in cell cycle regulation. This compound's interaction with Cdk2 modulates cellular processes, offering potential impacts on relevant pathways.