Cdc37 Activators

Cdc37 activators belong to a chemical class of compounds that are designed to interact with and modulate the activity of the Cdc37 protein. Cdc37 is a co-chaperone protein that plays a critical role in the proper folding and stabilization of a specific subset of client proteins known as protein kinases. These activators are developed to influence the interactions and functions of Cdc37, which in turn can impact the maturation and stability of protein kinases.

Cdc37 is an integral part of the cellular machinery responsible for maintaining protein homeostasis. It functions as a chaperone in association with the Hsp90 (heat shock protein 90) complex, assisting in the folding and stability of protein kinases, which are essential regulators of various cellular processes, including cell growth, proliferation, and signal transduction. Cdc37 activators, as the name suggests, are designed to enhance the activity of Cdc37 and facilitate its interaction with protein kinases. This modulation of Cdc37 activity can have downstream effects on the proper folding and function of specific protein kinases, impacting various cellular pathways and processes.