Cdc28 Activators
Cdc28 activators constitute a group of chemicals that intricately regulate the activity of the cell cycle regulator Cyclin-Dependent Kinase 28 (Cdc28). One prominent member of this class is Roscovitine (CAS Number: 186692-46-6), a CDK inhibitor that indirectly activates Cdc28. Roscovitine achieves this by inhibiting CDKs, specifically releasing the inhibitory modulation on Cdc28. The relief of CDK-mediated inhibition promotes the activation of Cdc28, allowing it to play a pivotal role in cell cycle progression.
Another example, Purvalanol A (CAS Number: 212844-53-6), also a CDK inhibitor, disrupts CDK-mediated inhibition, leading to increased Cdc28 activity. The inhibition of CDKs by Purvalanol A results in the relief of negative modulation on Cdc28, promoting its activation. This mechanism illustrates the importance of fine-tuning Cdc28 activity through targeted CDK inhibition. These activators, including Flavopiridol, NU6027, AT7519, Olomoucine, Purvalanol B, SNS-032, Dinaciclib, RGB-286638, AZD5438, and R547, exhibit similar modes of action by inhibiting CDKs and thereby releasing the inhibitory modulation on Cdc28. This intricate regulation of Cdc28 activity is crucial for proper cell cycle progression, highlighting the significance of these chemicals in modulating key cellular processes governed by Cdc28.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NU6027 | 220036-08-8 | sc-215591 | 10 mg | $156.00 | 1 | |
An inhibitor of CDK2 that indirectly activates Cdc28. NU6027 inhibits CDK2, releasing the inhibitory modulation on Cdc28 and promoting its activation by disrupting the negative regulation exerted by CDK2 on Cdc28. | ||||||
AT7519 | 844442-38-2 | sc-364416 sc-364416A sc-364416B sc-364416C | 5 mg 10 mg 100 mg 1 g | $291.00 $341.00 $1046.00 $3126.00 | 1 | |
A multi-CDK inhibitor that indirectly activates Cdc28. AT7519 inhibits various CDKs, including CDK2, releasing the inhibitory modulation on Cdc28 and promoting its activation by disrupting the negative regulation exerted by CDKs on Cdc28. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Another member of the Purvalanol family that indirectly activates Cdc28. Purvalanol B inhibits CDKs, disrupting the negative modulation on Cdc28 and promoting its activation. The relief of CDK-mediated inhibition allows for increased Cdc28 activity. | ||||||
RGB-286638 | 784210-88-4 | sc-507523 | 250 mg | $285.00 | ||
An inhibitor of CDK4 and CDK6 that indirectly activates Cdc28. RGB-286638 inhibits CDK4 and CDK6, releasing the inhibitory modulation on Cdc28 and promoting its activation by disrupting the negative regulation exerted by CDK4 and CDK6 on Cdc28. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
A selective CDK1, 2, and 9 inhibitor that indirectly activates Cdc28. AZD5438 inhibits CDKs, releasing the inhibitory modulation on Cdc28 and promoting its activation by disrupting the negative regulation exerted by CDKs on Cdc28. | ||||||
R547 | 741713-40-6 | sc-364596 sc-364596A | 2 mg 5 mg | $375.00 $395.00 | ||
A selective inhibitor of CDK1, 2, and 4 that indirectly activates Cdc28. R547 inhibits CDKs, alleviating the inhibitory modulation on Cdc28 and promoting its activation by disrupting the negative regulation exerted by CDKs on Cdc28. | ||||||