Date published: 2026-4-1

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CD97 Inhibitors

CD97 inhibitors are a class of chemical compounds that primarily target the CD97 receptor. CD97, also known as ADGRE5 (Adhesion G protein-coupled receptor E5), is a cell surface protein that belongs to the G protein-coupled receptor (GPCR) family. It is primarily expressed on the surface of various immune cells, including leukocytes and macrophages, as well as on endothelial cells. CD97 plays a crucial role in mediating cell adhesion and migration, particularly in the context of inflammation and immune responses. Inhibitors of CD97 are designed to modulate the activity of this receptor, potentially influencing various cellular processes associated with immune cell trafficking and inflammation. The mechanism of action of CD97 inhibitors involves their interaction with the CD97 receptor, either by blocking its activation or altering its downstream signaling pathways. By doing so, these inhibitors can influence immune cell adhesion, migration, and recruitment to inflammatory sites. This class of compounds may have implications in various pathological conditions where excessive immune cell infiltration and inflammation are involved. Research into CD97 inhibitors is ongoing, with a focus on understanding their precise molecular interactions with the CD97 receptor and their potential for modulating immune responses.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Pertussis Toxin (islet-activating protein)

70323-44-3sc-200837
50 µg
$451.00
3
(1)

Pertussis toxin can indirectly inhibit CD97 signaling by preventing G-protein coupling, which is necessary for CD97-mediated signal transduction.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a potent inhibitor of PI3K, a kinase involved in the downstream signaling of CD97. By inhibiting PI3K, it can indirectly affect CD97's function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is another PI3K inhibitor, which can indirectly inhibit CD97 signaling by blocking the PI3K-AKT signaling pathway.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$94.00
$227.00
30
(1)

PP2 is an Src family kinase inhibitor. Src kinases can be downstream of CD97, and thus PP2 can indirectly diminish CD97 signaling.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Dasatinib inhibits multiple tyrosine kinases, including Src family kinases, which can be involved in CD97-mediated signaling pathways, thus indirectly inhibiting CD97.

BAPTA/AM

126150-97-8sc-202488
sc-202488A
25 mg
100 mg
$138.00
$458.00
61
(2)

BAPTA-AM is a calcium chelator, and since calcium signaling can be involved in CD97 signaling, this compound can indirectly affect CD97 function.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), indirectly affecting CD97 signaling pathways that depend on calcium.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059 is a MEK inhibitor, which can indirectly inhibit CD97 by blocking the MAPK/ERK pathway, a potential downstream signaling route of CD97.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a JNK inhibitor, which may affect CD97 signaling by preventing JNK-mediated responses in pathways where CD97 is involved.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor which can indirectly disrupt CD97 signal transduction by inhibiting p38 MAPK activity, a potential component of CD97 signaling.