CD97 Inhibitors

CD97 inhibitors are a class of chemical compounds that primarily target the CD97 receptor. CD97, also known as ADGRE5 (Adhesion G protein-coupled receptor E5), is a cell surface protein that belongs to the G protein-coupled receptor (GPCR) family. It is primarily expressed on the surface of various immune cells, including leukocytes and macrophages, as well as on endothelial cells. CD97 plays a crucial role in mediating cell adhesion and migration, particularly in the context of inflammation and immune responses. Inhibitors of CD97 are designed to modulate the activity of this receptor, potentially influencing various cellular processes associated with immune cell trafficking and inflammation. The mechanism of action of CD97 inhibitors involves their interaction with the CD97 receptor, either by blocking its activation or altering its downstream signaling pathways. By doing so, these inhibitors can influence immune cell adhesion, migration, and recruitment to inflammatory sites. This class of compounds may have implications in various pathological conditions where excessive immune cell infiltration and inflammation are involved. Research into CD97 inhibitors is ongoing, with a focus on understanding their precise molecular interactions with the CD97 receptor and their potential for modulating immune responses.