CD38 Activators

Common CD38 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, Fludarabine CAS 21679-14-1, Cyclosporin A CAS 59865-13-3 and 5-Azacytidine CAS 320-67-2.

CD38, a type II transmembrane glycoprotein, is widely recognized for its multifaceted roles in cellular processes, including calcium signaling, cell adhesion, and cyclic ADP-ribose synthesis. Historically, CD38 was first identified on the surface of thymocytes and later on a variety of cells, including B cells, T cells, and natural killer cells. This molecule functions primarily as an enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+. The generated cADPR acts as a secondary messenger for calcium mobilization within cells, modulating various physiological processes. CD38 also has ADP-ribosyl cyclase and hydrolase activities, underlining its multifunctional enzymatic nature. Beyond its enzymatic roles, CD38 participates in cell-to-cell adhesion and signaling, especially in the context of immune responses.

CD38 Activators are chemical compounds devised to stimulate or augment the activity of CD38. By enhancing CD38's enzymatic functions, these activators influence its role in calcium signaling and NAD+ metabolism, thereby modulating related cellular events. Given the importance of calcium as a signaling molecule in various cellular processes, the controlled activation of CD38 might have profound impacts on cellular physiology, particularly in immune cells where CD38 is abundantly expressed. Activating CD38 could also impact NAD+ levels, given the enzyme's role in its metabolism. Understanding the mechanisms and effects of CD38 activators is crucial for gaining insights into the intricate balance of calcium signaling and NAD+ regulation in various cellular contexts. The exploration of CD38 activators can offer a deeper understanding of the protein's diverse functionalities and its impact on cellular homeostasis and communication.