CCDC65 Inhibitors

The chemical class of CCDC65 (Dynein Regulatory Complex Subunit 2) Inhibitors, as compiled, is focused on compounds that influence microtubule dynamics or motor protein functions, which are crucial for ciliary and flagellar motility. These inhibitors target processes that are indirectly related to CCDC65's role in the assembly and function of the nexin-dynein regulatory complex (N-DRC) and its interaction with microtubules. Compounds like Taxol, Vinblastine, and Colchicine are known for their ability to modulate microtubule dynamics by either stabilizing or disrupting microtubule assembly. Since CCDC65 is involved in microtubule organization within cilia and flagella, altering the stability and dynamics of microtubules can indirectly influence the function of CCDC65. These changes in microtubule dynamics can affect the alignment, integrity, and motility of cilia and flagella, thereby impacting the cellular processes in which these structures are involved.

Additionally, inhibitors like Nocodazole and Vincristine specifically disrupt microtubule polymerization, which could have implications for the microtubule-dependent roles of CCDC65. In contrast, compounds such as Eribulin and Docetaxel stabilize microtubules, offering a different mechanism by which the microtubule-related functions of CCDC65 could be influenced. Furthermore, the inclusion of Kinesin Spindle Protein (KSP) inhibitors, dynein motor inhibitors, and specific kinase inhibitors like Alisertib reflects the complexity of the cellular machinery involved in microtubule dynamics and motor protein functions. By targeting these components, the inhibitors can indirectly modulate the environment in which CCDC65 operates, affecting its function in ciliary and flagellar motility. In summary, this chemical class provides an indirect approach to influencing CCDC65 function by targeting related microtubule dynamics and motor protein functions. Understanding the interplay between these inhibitors and the microtubule machinery is essential for exploring research related to diseases and disorders involving ciliary and flagellar dysfunction.