CCDC41 Activators
CCDC41, also known as Centrosome and Spindle Pole Associated Protein 1 (CSPP1), plays a significant role in centrosome cohesion and spindle pole organization, which are vital processes during cell division. This protein is essential for ensuring that chromosomes are accurately separated into daughter cells during mitosis, a critical aspect of cellular reproduction and tissue growth. The function of CCDC41 in centrosome and spindle pole maintenance helps to prevent the occurrence of chromosomal instability, a common feature of many cancers, and is therefore fundamental for maintaining genomic integrity. Additionally, CCDC41 has been implicated in ciliogenesis, the process by which cells build cilia. Cilia are small hair-like structures on cell surfaces that are involved in signaling pathways and cellular movement, as well as sensory functions.
The activation of CCDC41 is a complex process that likely involves multiple regulatory mechanisms. One primary mode of activation could be through post-translational modifications, such as phosphorylation, which are common regulatory mechanisms for proteins involved in cell cycle control. Phosphorylation of CCDC41 could induce changes in its conformation, enhancing its ability to interact with other centrosomal proteins or microtubules, thus facilitating its role in spindle assembly and centrosome cohesion. Another significant aspect of CCDC41 activation involves its localization within the cell. During specific phases of the cell cycle, particularly mitosis, CCDC41 may be actively transported to the centrosomes or spindle poles where it exerts its effects. This localization is crucial for its function and could be mediated by interactions with other centrosomal proteins or by recognition of specific cellular structures through its coiled-coil domains, which are known to mediate protein-protein interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can initiate multiple intracellular events. If CCDC41 is involved in any cAMP-modulated pathway, Forskolin's action can indirectly modulate CCDC41's activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a phosphodiesterase inhibitor, resulting in increased intracellular cAMP levels. By preventing cAMP breakdown, IBMX can indirectly influence pathways or proteins, such as CCDC41, that may be modulated by cAMP. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC). If CCDC41 has any involvement in PKC-modulated pathways or processes, PMA's action on PKC can indirectly influence CCDC41. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Another phosphodiesterase inhibitor, Rolipram leads to elevated cAMP levels. If CCDC41 participates in a pathway influenced by cAMP, Rolipram's action can provide an indirect effect on CCDC41. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is also a phosphodiesterase inhibitor. By influencing the cAMP pathway, any proteins or processes associated with cAMP modulation, potentially including CCDC41, can be indirectly influenced by Cilostazol. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator. If CCDC41 is involved in pathways or processes modulated by JNK activity, Anisomycin's effect on JNK can offer an indirect influence on CCDC41. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation. If CCDC41 functions within or in relation to NF-κB pathways, BAY 11-7082's action can indirectly modulate CCDC41 through altered NF-κB activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent protein phosphatase inhibitor. If CCDC41's function or activity is influenced by phosphorylation events, Calyculin A can indirectly modulate CCDC41 by affecting protein phosphatase activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As another protein phosphatase inhibitor, Okadaic Acid can influence proteins whose activity or function is tied to phosphorylation events. If CCDC41 operates within such contexts, Okadaic Acid can offer indirect modulation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate inhibits protein tyrosine phosphatases. If CCDC41 is involved in pathways influenced by tyrosine phosphorylation, the inhibition of these phosphatases can indirectly impact CCDC41's activity. | ||||||