CCDC34 Inhibitors
CCDC34 Inhibitors encompass a range of chemical compounds that influence cellular pathways and processes which CCDC34 is directly involved in, primarily those related to cell cycle regulation and mitosis. Wortmannin and Triciribine target the PI3K/Akt pathway, a signaling cascade vital for various cellular processes, including cell cycle progression. The inhibition of PI3K or Akt could prevent the phosphorylation and activation of downstream targets necessary for the cell cycle phases where CCDC34 is required, resulting in its functionalinhibition. Similarly, compounds like Palbociclib, Roscovitine, and PD0332991 target cyclin-dependent kinases (CDKs), which are essential for the cell cycle transitions. As CCDC34 is implicated in cell cycle progression, inhibition of CDKs can halt the cell cycle at checkpoints where CCDC34 activity is crucial, thereby indirectly inhibiting its function. The specific blockage of cell cycle phases by these inhibitors would prevent CCDC34 from exerting its role during the cell division process, particularly if its activity is temporally coordinated with those phases.
Furthermore, compounds such as AZD8055, Nocodazole, and Vinorelbine disrupt the function of cellular structures and processes that are fundamental for mitotic progression. AZD8055, as an mTOR inhibitor, could reduce the activity of CCDC34 by interfering with the signaling that regulates protein synthesis and cell growth, processes that are potentially linked with CCDC34 function. Nocodazole and Vinorelbine, which perturb microtubule dynamics, would indirectly inhibit CCDC34 by causing mitotic arrest, assuming that CCDC34 is involved in spindle assembly or chromosome segregation. Inhibitors targeting Aurora kinases (e.g., MLN8237, ZM447439, Alisertib) and Plk1 (e.g., BI 2536) also function to halt mitosis at stages where CCDC34 might be active.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it prevents the phosphorylation and activation of Akt. Since CCDC34 is involved in cell cycle progression, its activity could be compromised by reduced Akt signaling, leading to cell cycle arrest at a phase where CCDC34 is critical. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is a specific Akt inhibitor that prevents the phosphorylation and activation of Akt. If CCDC34 function is regulated by Akt-mediated signaling for its stability or localization during cell division, inhibition of Akt by Triciribine would lead to functional inhibition of CCDC34. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is an inhibitor of CDKs, including CDK2, which is necessary for the G1 to S phase transition. If CCDC34 has functions related to S phase entry, the inhibition of CDK2 by Roscovitine would result in an indirect inhibition of CCDC34 activity. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is an mTOR inhibitor which could disrupt the mTORC1 and mTORC2 complexes. Inhibition of mTOR can impede cell cycle progression and protein synthesis. If CCDC34 is a downstream target of mTOR signaling, its activity would be compromised by AZD8055. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, leading to cell cycle arrest at the M phase. If CCDC34 is involved in processes like spindle assembly or chromosome segregation, inhibition of microtubule function by Nocodazole would indirectly inhibit the function of CCDC34. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $29.00 $81.00 $260.00 $791.00 $1977.00 | ||
Vinorelbine is a microtubule destabilizer that can arrest cells in the M phase of the cell cycle. If CCDC34 is active during mitosis, particularly in spindle function or cytokinesis, its function would be inhibited by the microtubule disruption caused by Vinorelbine. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
MLN8237 is an Aurora A kinase inhibitor. As Aurora A kinase is essential for mitotic entry and spindle assembly, inhibition by MLN8237 could arrest cells before mitosis, thereby inhibiting CCDC34 if it functions during these cell cycle stages. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an inhibitor of Aurora kinases, which play a role in chromosome alignment and segregation during mitosis. If CCDC34 functions in coordination with these processes, its activity would be indirectly inhibited by ZM447439. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a Plk1 inhibitor that leads to mitotic arrest. Since CCDC34 is potentially involved in mitotic progression, inhibition of Plk1 by BI 2536 would lead to an indirect inhibition of CCDC34 function during mitosis. | ||||||