Date published: 2025-12-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

CB2 Activators

CB2 Activators are chemicals that either directly enhance the functional activity of CB2, a protein known to be involved in immunomodulatory functions. Most of these compounds are selective CB2 agonists, meaning they bind specifically to CB2 receptors and trigger a series of intracellular signaling events that lead to the activation of CB2. This activation can lead to the initiation of CB2's downstream effects, which are largely associated with immunomodulatory functions. Examples of these compounds include JWH-133, AM1241, HU-308, GW842166X, L-759633, and L-759656. These compounds, by binding to CB2, enhance its functional activity and so enhance the immunomodulatory roles of CB2. Other compounds like BAY 59-3074, UR-144, A-836339, AM1714, JTE-907, and LY2828360 also act by binding to CB2 and triggering intracellular signaling events that enhance the functional activity of CB2. These compounds also lead to heightened immunomodulatoryeffects associated with CB2. The binding of these compounds to CB2 triggers signaling cascades that in turn heighten the functional activity of CB2, thereby enhancing the execution of its immunomodulatory roles. The mechanisms of action by which these CB2 activators function underline the key role of CB2 in immune regulation. The selective nature of these compounds suggests specific and targeted activation of CB2, thus illustrating the critical role of CB2 in modulating immune responses.

SEE ALSO...

Items 1 to 10 of 25 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SR 144528

192703-06-3sc-224292
sc-224292A
5 mg
10 mg
$282.00
$539.00
6
(1)

SR 144528 is a selective CB2 receptor antagonist known for its unique binding affinity and specificity. Its structural features facilitate distinct hydrogen bonding interactions, which enhance receptor selectivity. The compound exhibits unique conformational flexibility, allowing it to adopt various spatial arrangements that optimize its interaction with the CB2 receptor. Additionally, its hydrophobic characteristics influence its solubility and distribution in lipid environments, affecting its overall bioavailability.

Magnolol

528-43-8sc-204797
sc-204797A
5 mg
25 mg
$42.00
$185.00
1
(0)

Magnolol is a compound that exhibits notable interactions with the CB2 receptor, characterized by its ability to stabilize receptor conformations through specific hydrophobic and van der Waals interactions. Its unique structural arrangement allows for effective modulation of receptor signaling pathways, influencing downstream effects. The compound's lipophilicity enhances its membrane permeability, facilitating rapid cellular uptake and influencing its kinetic behavior in biological systems.

GP 1a

511532-96-0sc-203980
sc-203980A
10 mg
50 mg
$313.00
$1288.00
(0)

GP 1a is a selective ligand for the CB2 receptor, demonstrating unique binding dynamics through its intricate hydrogen bonding and electrostatic interactions. This compound's structural features promote a distinct conformational change in the receptor, enhancing its affinity and selectivity. Additionally, GP 1a's high lipophilicity contributes to its rapid diffusion across lipid membranes, impacting its distribution and interaction kinetics within cellular environments.

GP 2A

919077-81-9sc-203588
sc-203588A
10 mg
50 mg
$410.00
$1250.00
(0)

GP 2A acts as a selective ligand for the CB2 receptor, characterized by its unique molecular interactions that facilitate specific receptor conformations. Its distinct steric properties enable effective docking, while the presence of halogen substituents enhances its reactivity and binding affinity. The compound exhibits notable stability in various environments, influencing its kinetic profile and interaction pathways, which are crucial for modulating receptor activity.

ABN-CBD

22972-55-0sc-203488A
sc-203488B
sc-203488
sc-203488C
1 mg
5 mg
10 mg
25 mg
$36.00
$143.00
$235.00
$541.00
1
(0)

ABN-CBD functions as a selective modulator of the CB2 receptor, showcasing unique binding dynamics that promote receptor activation. Its structural configuration allows for optimal spatial orientation, enhancing interaction with the receptor's active site. The presence of halogen atoms contributes to its electronic properties, facilitating stronger intermolecular forces. This compound also demonstrates a distinctive kinetic behavior, influencing the rate of receptor engagement and subsequent signaling cascades.

CP-55,940

83002-04-4sc-200359
sc-200359A
5 mg
25 mg
$185.00
$850.00
4
(1)

CP-55,940 exhibits a remarkable affinity for the CB2 receptor, characterized by its ability to stabilize receptor conformations through specific hydrogen bonding and hydrophobic interactions. The compound's unique stereochemistry enhances its selectivity, allowing for precise modulation of receptor activity. Additionally, its lipophilic nature promotes efficient membrane permeability, influencing its distribution and interaction kinetics within biological systems. This compound's dynamic behavior in receptor binding contributes to its nuanced signaling pathways.

(R)-Methanandamide

157182-49-5sc-200792
sc-200792A
5 mg
25 mg
$56.00
$175.00
1
(1)

(R)-Methanandamide is a selective agonist for the CB2 receptor, distinguished by its unique stereochemical configuration that facilitates specific interactions with receptor binding sites. Its molecular structure allows for effective van der Waals forces and electrostatic interactions, enhancing receptor activation. The compound's high lipophilicity aids in rapid cellular uptake, influencing its pharmacokinetic profile and enabling nuanced modulation of downstream signaling pathways. Its behavior in receptor dynamics showcases a complex interplay of affinity and efficacy.

GW-405833

180002-83-9sc-200373
sc-200373A
10 mg
50 mg
$102.00
$319.00
(0)

GW-405833 is a selective CB2 receptor agonist characterized by its unique binding affinity and interaction dynamics. Its structural conformation promotes specific hydrogen bonding and hydrophobic interactions, optimizing receptor engagement. The compound exhibits a distinct kinetic profile, with a rapid onset of action and prolonged receptor occupancy. This results in a finely tuned modulation of intracellular signaling cascades, highlighting its role in influencing cellular responses through targeted receptor activation.

GW 842166X

666260-75-9sc-205338
sc-205338A
1 mg
5 mg
$27.00
$122.00
(0)

GW842166X is a potent and selective CB2 agonist. It binds to CB2 receptors, enhancing their functional activity by triggering signaling events that lead to the activation of CB2. This activation can enhance the immunomodulatory effects associated with CB2.

CB 13

432047-72-8sc-203870
sc-203870A
10 mg
50 mg
$115.00
$473.00
(0)

CB 13 is a selective CB2 receptor agonist distinguished by its unique molecular architecture, which facilitates specific electrostatic interactions and conformational flexibility. This compound demonstrates a notable ability to stabilize receptor conformations, enhancing ligand-receptor affinity. Its reaction kinetics reveal a biphasic binding pattern, allowing for both rapid initial engagement and sustained interaction, thereby influencing downstream signaling pathways with precision and efficacy.