CatSper2 Activators
CatSper2 activators comprise a diverse array of chemical compounds that enhance the activity of CatSper2, a calcium channel essential for sperm motility and the acrosome reaction. Progesterone stands out as a direct activator, binding to the CatSper complex and sharply increasing calcium influx through CatSper2, thereby playing a critical role in the hyperactivation of sperm motility. This steroid hormone operates by directly modulating the CatSper2 channel activity, which is pivotal for the physiological process of fertilization. Other activators, while not binding directly to the CatSper2 channel, influence its activity indirectly by altering the intracellular environment or modulating secondary signaling pathways that affect CatSper2 function. For instance, compounds that modify the membrane potential or intracellular concentrations of ions such as calcium and sodium can increase the driving force for calcium entry through CatSper2. Additionally, some activators work by inhibiting other channels or pumps, leading to changes in cellular homeostasis that result in the upregulation of CatSper2 channel activity.
These indirect activators include various pharmacological agents such as ion channel blockers, kinase inhibitors, and hormone analogs, each contributing to the complex regulation of CatSper2. Agents like forskolin, which elevate cAMP levels, can potentiate CatSper2 activity by enhancing the downstream signaling pathways that increase calcium influx. On the other hand, inhibitors of other ion channels may cause compensatory increases in CatSper2 activity to maintain the required ionic balances for sperm capacitation and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, a steroid hormone, engages with CatSper ion channels in sperm to enhance calcium influx, which is crucial for sperm motility and fertilization processes. By binding to the CatSper2 subunit, Progesterone amplifies the calcium signaling that is essential for the hyperactivated motility of sperm. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
4-Aminopyridine is a potassium channel blocker that increases the duration of action potentials, which influences the intracellular calcium levels. Elevated calcium levels can potentially enhance the activity of CatSper2 by promoting calcium influx in sperm cells, which is vital for sperm activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, is known to affect calcium channels. By inhibiting certain kinases, Genistein may lead to an upregulation of calcium signaling pathways that indirectly activate CatSper2 channels, intensifying the calcium influx necessary for sperm motility. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions play a pivotal role in modulating ion channels, including calcium channels. Zinc can potentiate CatSper2 activity by stabilizing the channel structure or altering its conformation, thus enhancing calcium influx in sperm and contributing to motility and the acrosome reaction. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP levels may indirectly stimulate CatSper2 by enhancing the overall calcium signaling environment within sperm cells, which is critical for their hyperactivated state required for fertilization. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, a vanilloid receptor agonist, influences calcium signaling pathways. By activating these pathways, capsaicin could indirectly augment the activity of CatSper2, thereby increasing calcium influx in sperm that is essential for their function in fertilization. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid is a known blocker of certain chloride channels but has also been reported to influence calcium channels. Its modulation of ionic homeostasis could lead to enhanced activation of CatSper2 by indirectly increasing intracellular calcium levels in sperm, thus affecting motility and fertilization capability. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 acts as an L-type calcium channel agonist, which can lead to increased intracellular calcium levels. By promoting calcium influx, this compound may enhance the activity of CatSper2, indirectly contributing to the hyperactivated motility of sperm. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterase enzymes, leading to an increase in cAMP levels, which can modulate various ion channels, including calcium channels. The resultant alteration in calcium signaling may enhance the activity of CatSper2, indirectly facilitating the increased calcium influx necessary for sperm motility and function in fertilization. | ||||||