CatSper2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil blocks T-type calcium channels, which can indirectly inhibit CatSper2 by altering the calcium influx necessary for CatSper2 channel function in sperm. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is an L-type calcium channel blocker that could reduce the overall calcium levels impacting CatSper channels due to the interconnectedness of calcium homeostasis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, another calcium channel blocker, can indirectly inhibit CatSper2 by reducing calcium entry through L-type channels, which can lower intracellular calcium concentration required for CatSper2 activity. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a local anesthetic that blocks voltage-gated sodium channels, potentially reducing the action potentials necessary for calcium influx affecting CatSper2 activity. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride indirectly inhibits CatSper2 by modulating the sodium/hydrogen exchanger and thus altering intracellular pH, which is a known regulator of CatSper channel function. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole inhibits cytochrome P450 enzymes, which may indirectly affect the steroid hormone synthesis that regulates CatSper2 channel functionality. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole, known to inhibit cytochrome P450 enzymes and Ca2+-activated K+ channels, could alter the calcium and potassium ionic environment, impacting CatSper2 activity. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide, a diuretic, can affect ion concentrations, especially Ca2+ homeostasis, which in turn can indirectly inhibit CatSper2 by altering its ionic operating environment. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine blocks voltage-gated sodium channels, which could diminish the depolarization required for optimal CatSper2 channel functioning. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Flufenamic acid is another NSAID that can block other Ca2+ channels, potentially affecting intracellular Ca2+ levels and indirectly inhibiting CatSper2. | ||||||