CaM IV Activators
CaM IV Activators are a diverse range of compounds that influence the protein's function through various mechanisms, primarily related to the modulation of intracellular calcium levels and cAMP-dependent signaling pathways. Calcium is a key activator of CaM IV and many of these compounds work by facilitating calcium influx or inhibiting calcium efflux, thereby increasing intracellular calcium concentrations. For instance, A23187 and Thapsigargin are potent tools for increasing intracellular calcium levels, which in turn leads to CaM IV activation. Similarly, Nifedipine, Bay K 8644, and Verapamil mediate their actions through interaction with calcium channels, indirectly leading to heightened intracellular calcium levels and subsequent CaM IV activation.
Additionally, the role of cAMP-dependent signaling in the function of CaM IV is highlighted by the action of compounds such as Forskolin and IBMX. These compounds enhance the intracellular levels of cAMP, leading to the activation of Protein Kinase A (PKA). PKA can phosphorylate and activate CaM IV, linking cAMP-dependent signaling to the functional activity of CaM IV. Isoproterenol, a beta-adrenergic agonist, also operates on this pathway by stimulating adenylyl cyclase and increasing cAMP levels. Finally, some compounds such as Chelerythrine Chloride and Calmidazolium Chloride operate by inhibiting competing signaling pathways or through feedback mechanisms, ultimately leading to CaM IV activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylyl cyclase, which can increase intracellular cAMP levels. This can lead to the activation of Protein Kinase A (PKA), which can phosphorylate and activate CaM IV. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-specific inhibitor of phosphodiesterases, which helps increase intracellular cAMP levels, potentially leading to PKA activation and subsequent CaM IV activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased intracellular calcium levels and hence CaM IV activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A mobile ion carrier that transports calcium across biological membranes, leading to increased intracellular calcium levels and hence CaM IV activation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
A calcium channel blocker that can indirectly increase intracellular calcium levels via feedback mechanisms, potentially leading to CaM IV activation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
An L-type calcium channel agonist that can increase intracellular calcium levels, leading to CaM IV activation. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Another calcium channel blocker that can indirectly increase intracellular calcium levels via feedback mechanisms, potentially leading to CaM IV activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that stimulates adenylyl cyclase, increasing cAMP levels, and thereby potentially leading to PKA activation and subsequent CaM IV activation. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Modulates intracellular calcium release channels, increasing intracellular calcium levels and thus leading to CaM IV activation. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
An inhibitor of Protein Kinase C (PKC), which can indirectly lead to increased intracellular calcium levels and subsequent CaM IV activation. | ||||||