C9orf40 Activators
Forskolin and IBMX elevate intracellular cAMP levels, which in turn activate PKA, a kinase with the capacity to phosphorylate numerous proteins. This phosphorylation can lead to modifications in protein activity, potentially affecting proteins akin to C9orf40. Other molecules, such as PMA, act as activators of protein kinase C (PKC), ushering in the phosphorylation of a variety of substrates. In parallel, ionophores like Ionomycin and A23187 disrupt calcium homeostasis, triggering calcium-dependent signaling mechanisms that could intersect with the regulatory domains of proteins similar to C9orf40. LY294002, U0126, and SB203580 are representatives that target the core of signaling cascades such as PI3K/AKT and MAPK/ERK. These inhibitors modulate the phosphorylation status and activity of kinases within these pathways, which can have a bearing on the activity of proteins governed by these cascades.
Furthermore, epigenetic modifiers like Trichostatin A and 5-Azacytidine induce alterations in gene expression patterns through their inhibition of histone deacetylases and DNA methyltransferases, respectively. These changes in the chromatin landscape can consequently affect the expression and function of a wide array of proteins. The Aurora kinase inhibitor ZM-447439 adds to this arsenal by influencing cell cycle progression and potentially affecting proteins involved in this fundamental cellular process.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, raises cAMP levels, thereby enhancing PKA activation and possible subsequent protein phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate a wide range of proteins, possibly including C9orf40. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium, possibly activating calcium-dependent proteins and enzymes that may modify C9orf40. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore which can mimic ionomycin's effects and potentially affect C9orf40 activity through calcium signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which can lead to a cascade of events resulting in the activation of proteins downstream of the AKT pathway, potentially C9orf40. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK, which could lead to the activation of proteins that are regulated by the ERK pathway, potentially including C9orf40. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, which can affect substrates in the MAPK pathway, possibly impacting C9orf40. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that can alter the activity within the MAPK/ERK pathway, thereby influencing the function of associated proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylases, leading to changes in chromatin structure and gene expression, which might affect C9orf40 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, could lead to gene expression changes, indirectly affecting protein function, including possibly C9orf40. | ||||||