C9orf173 Inhibitors

LY294002 and Triciribine are inhibitors of the PI3K/AKT pathway, a critical axis in the regulation of cell growth and survival. Inhibition of this pathway by these chemicals can lead to considerable modulation of cellular functions, potentially impacting proteins associated with this pathway. SP600125, Rapamycin, and Staurosporine target stress response, mTOR signaling, and multiple kinases, respectively. These pathways are integral to the proper functioning of cellular processes, including metabolism, growth, and apoptosis. Inhibiting these pathways can have broad effects on the activity of proteins that are involved in or affected by these pathways.

PD98059 and U0126 are specific inhibitors of the MEK enzymes, and by extension, the MAPK/ERK signaling pathway, which is pivotal in cell proliferation and differentiation. GW5074 and Chelerythrine target c-Raf and PKC, respectively, influencing the cell cycle and apoptotic processes. The impact on these pathways can alter the behavior of proteins that are part of these pathways or are regulated by them. ZM-447439 and Thapsigargin affect cell division and calcium homeostasis, respectively. ZM-447439's inhibition of Aurora kinases can disrupt the mitotic process, while Thapsigargin's disruption of calcium signaling can lead to a cascade of effects on cellular survival and signaling. 2-D08's inhibition of the SUMOylation process can lead to widespread changes in protein function and localization, which may affect proteins that interact with or are regulated by the SUMOylation process.